Single Nucleotide Polymorphism of Exo1 Gene: Association with Gastric Cancer Susceptibility and Interaction with Smoking in Taiwan

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Title:	Single Nucleotide Polymorphism of Exo1 Gene: Association with Gastric Cancer Susceptibility and Interaction with Smoking in Taiwan
Authors:	包大靝(Da-Tian Bau);王惠暢(Hwei-Chung Wang);劉秋松(Chiu-Shong Liu);(Chia-Lin Chang);(Chin-Fen Lin);(Su-Yin Chiang);(Shiu-Yun Liang);(Yen-Li Lo);(Chao A. Hsiung);林正介(Cheng-Chieh Lin);黃志揚(Chih-Yang Huang)
Contributors:	中醫學院中國醫學研究所;中國附醫泰瑞法克斯癌症研究實驗室
Keywords:	Exo1;polymorphism;gastric cancer;carcinogenesis
Date:	2009
Issue Date:	2009-08-20 17:48:06 (UTC+8)
Abstract:	Exonuclease 1 (Exo1) is an important nuclease involved in the mismatch repair system that contributes to the maintenance of genomic stability, modulation of DNA recombination and mediation of cell cycle arrest. Potential polymorphisms in Exo1 may alter cancer risks by influencing the repair activity of Exo1. We hypothesized that single-nucleotide polymorphisms (SNPs) in Exo1 might be associated with risks of gastric cancer. In this hospital-based study, the association of Exo1 A-1419G (rs3754093), C-908G (rs10802996), A238G (rs1776177), C498T (rs1635517), K589E (rs1047840), G670E (rs1776148), C723R (rs1635498), L757P (rs9350) and C3114T (rs851797) polymorphisms with gastric cancer risk in a central Taiwanese population was investigated. In total, 179 patients with gastric cancer and 179 age- and gender-matched healthy controls recruited from the China Medical Hospital in central Taiwan were genotyped. A significantly different distribution was found in the frequency of the Exo1 K589E genotype, but not the other genotypes, between the gastric cancer and control groups. The A allele Exo1 K589E conferred a significant (P = 0.0094) increased risk of gastric cancer. Geneenvironment interactions with smoking were significant for Exo1 K589E polymorphism, which showed that the Exo1 K589E AG/AA genotype in association with smoking conferred an increased risk of 2.07- fold (95% confidence interval = 1.22-3.50) for gastric cancer. Our results provide the first evidence that the A allele of the Exo1 K589E may be associated with the development of gastric cancer and may be a novel and useful marker for primary prevention and anticancer intervention.
Relation:	CHINESE JOURNAL OF PHYSIOLOGY 52(6):411-418
Appears in Collections:	[Graduate Institute of Chinese Medical Science] Journal articles

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