Effects of fenoterol and ipratropium on respiratory resistance of asthmatics after tracheal intubation

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Title:	Effects of fenoterol and ipratropium on respiratory resistance of asthmatics after tracheal intubation
Authors:	Wu, RSC;Wu, KC;Wong, TKM;Tsai, YH;Cheng, RKS;Bishop, MJ;Tan, PPC
Contributors:	附設醫院 China Med Coll Hosp, Taichung, Taiwan
Date:	2000
Issue Date:	2010-09-20 13:55:00 (UTC+8)
Publisher:	PROF SCI PUBL
Abstract:	We have studied the effects of a beta-agonist, fenoterol, and a cholinergic antagonist, ipratropium, on post-intubation total respiratory system resistance (Rrs) in asthmatics who developed increased Rrs after tracheal intubation. Sixteen stable asthmatics in whom Rrs increased after intubation were allocated randomly to receive either 10 puffs of fenoterol (group F) or 10 puffs of ipratropium (group 1B) via a metered dose inhaler 5 min after intubation. Anaesthesia was induced and maintained with propofol i.v. Rrs was recorded before treatment and again 5, 15 and 30 min after treatment. Rrs decreased significantly from pretreatment values by mean 53 (SD 8)%, 53 (7)% and 58 (6)% at 5, I 5 and 30 min, respectively, in group F, but declined by only 12 (6)%, 15 (4)% and 17 (5)% in group 1B, At all times after treatment, patients in the fenoterol group had significantly tower Rrs values than those in the ipratropium group. We conclude that increased Rrs after tracheal intubation in asthmatics can be reduced effectively by treatment with fenoterol. A secondary finding of our study was that even after induction of anaesthesia with propofol, patients with a history of asthma may develop high Rrs.
Relation:	BRITISH JOURNAL OF ANAESTHESIA 84(3):358-362
Appears in Collections:	[China Medical University Hospital] Proceedings

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