Construction of endophenotypes for complex diseases in the presence of heterogeneity

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Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/27098

Title:	Construction of endophenotypes for complex diseases in the presence of heterogeneity
Authors:	Chen, CH;Kuo, CL;Lin, MCP;Liang, YJ;Fann, CSJ
Contributors:	中醫學院 China Med Univ, Coll China Med, Taichung, Taiwan;Acad Sinica, Inst Biomed Sci, Taipei, Taiwan;Natl Yang Ming Univ, Inst Publ Hlth, Taipei 112, Taiwan
Date:	2005
Issue Date:	2010-09-20 13:43:31 (UTC+8)
Publisher:	BIOMED CENTRAL LTD
Abstract:	Endophenotypes such as behavior disorders have been increasingly adopted in genetic studies for complex traits. For efficient gene mapping, it is essential that an endophenotype is associated with the disease of interest and is inheritable or co-segregating within families. In this study, we proposed a strategy to construct endophenotypes to analyze the Genetic Analysis Workshop 14 simulated dataset. Initially, generalized estimating equation models were employed to identify phenotypes that were correlated to the disease (affected status) in combination with the family structures in data. Endophenotypes were then constructed with consideration of heterogeneity as functions of the identified phenotypes. Genome scans on the constructed endophenotypes were carried out using family-based association analysis. For comparison, genome scans were also performed with the original affected status. The family-based association analysis using the endophenotypes correctly identified the same susceptible gene in about 80 of the 100 replicates.
Relation:	BMC GENETICS 6(suppl.1):139
Appears in Collections:	[School of Chinese Medicine] Proceedings

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