A clinicopathologic study of mucinous gastric carcinoma including multivariate analysis

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 中國醫藥大學 > 會議論文 > Item 310903500/27076

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题名:	A clinicopathologic study of mucinous gastric carcinoma including multivariate analysis
作者:	Wu, CY;Yeh, HZ;Shih, RTP;Chen, GH
贡献者:	中國醫藥大學 China Med Coll, Taichung, Taiwan
日期:	1998
上传时间:	2010-09-20 13:37:18 (UTC+8)
出版者:	WILEY-LISS
摘要:	BACKGROUND. Mucinous gastric carcinoma (MGC) is a rare subtype of gastric adenocarcinoma, and its clinical and pathologic features are still controversial. To clarify the significance of this subtype of carcinoma, the authors conducted a case-control study to investigate the clinicopathologic characteristics of MGC and determine whether this mucin-producing histologic type is associated with a worse prognosis than other gastric carcinomas. METHODS. Twenty-two cases of MGC and 46 patients with nonmucinous gastric carcinoma (NGC) were included. Patients were evaluated on the basis of age, gender, tumor size, location, depth of tumor invasion, histologic differentiation, lymph node involvement, organ metastasis, stage at presentation, surgical curability, adjuvant chemotherapy and radiation therapy. To determine whether the MGC itself was an independent prognostic factor, a multivariate analysis was performed with the Cox proportional hazards model. RESULTS. The MGC patients were found to have larger tumors (P < 0.001), tumors more often located in the upper stomach (P < 0.05), more serosal invasion (P < 0.05), more lymph node involvement (P < 0.05), greater frequency of advanced stage disease (P < 0.01), and lower 5-year survival rates (P ( 0.05) than NGC patients. There was no significant correlation between the subtypes of differentiation of MGC and other data, including the prognosis. Multivariate analysis showed that clinically important predictive factors were serosal invasion and disease stage at diagnosis. The mucinous histologic type itself was not an independent factor for poor prognosis. CONCLUSIONS. The overall survival rate for patients with MGC was worse than that for patients with NGC. The poor prognosis was correlated with more advanced stage at diagnosis and more frequent serosal invasion, not with the mucinous histologic type. Cancer 1998;83:1312-8. (C) 1998 American Cancer Society.
關聯:	CANCER 83(7):1312-1318
显示于类别:	[中國醫藥大學] 會議論文

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