Association of Vitamin D Receptor Gene Start Codon Fok I Polymorphism with Calcium Oxalate Stone Disease.

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 中醫學院 > 中西醫結合研究所 > 期刊論文 > Item 310903500/2692

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題名:	Association of Vitamin D Receptor Gene Start Codon Fok I Polymorphism with Calcium Oxalate Stone Disease.
作者:	陳汶吉(Chen Wen-Chi);陳慧毅(Huey-Yi Chen);呂學甫(Lu HF);許正德(Hsu CD);蔡輔仁(Fuu-Jen Tsai)
貢獻者:	中醫學院中西醫結合研究所;中國附醫泌尿部
關鍵詞:	vitamin D receptor polymorphism;urolithiasis;single nucleotide polymorphisms
日期:	2001
上傳時間:	2009-08-20 17:45:58 (UTC+8)
摘要:	Objective To assess the use of Fok I polymorphism (the most frequent polymorphism, at the start codon of the vitamin D receptor gene, VDR) as a convenient genetic marker in identifying the cause of urolithiasis. Patients, subjects and methods A normal control group of 90 healthy subjects and 146 patients with calcium oxalate stones were examined. Using polymerase chain reaction (PCR)-based restriction analysis, the relationship between Fok I polymorphism and urolithiasis was evaluated. An unexcisable length of 265 bp was identified (allele CC) and two fragments (169 bp and 96 bp) identified as excisable lengths (allele TT). Results There was a statistically significant difference between the groups (chi-square test, P < 0.05) for the genotype of the VDR Fok I start codon polymorphism. The odds ratio (95% confidence interval) for the C allele in those at risk of stone disease was 1.672 (1.149–2.432). Conclusions These results suggest that the VDR Fok I start codon polymorphism may be a good candidate for a genetic marker in calcium oxalate stone disease.
關聯:	BJU INTERNATIONAL (87):168~171
顯示於類別:	[中西醫結合研究所] 期刊論文

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