| 摘要: | ??病是一種複雜的慢性代謝疾病，包括胰島素依賴型(第一型)??病與非胰島素依賴型(第二型)??病。第一型??病一般是由於自體免疫系統破壞產生胰島素之β 細胞所導致的；第二型(或懷孕妊娠)??病是由於組織細胞產生胰島素抵抗，由於第ㄧ型與第二型??病之生?機制?同，所以我們將分?探討其機轉。?床上通常使用飲食控制、??藥物（對於2 型??病）和胰島素補充相結合治???病。但是??病如果沒有得到足夠的控制，將會引起一些急性併發症，?如高血?症(hyperglycemia)、酮症酸中毒(ketoacidosis)、非酮高滲性昏迷(nonketotic hyperosmolar coma)。而嚴重的長期併發症包括：心血管疾病、慢性腎衰竭、視網膜病變、微血管(microvascular)病變及?經病變(neuropathy)。??病疼痛性?經病變是??病最常?的併發症之一，並且以周邊?經病變 (peripheral neuropathy)所佔的比?最高，將近約60%的病患有??病周邊?經病變，其中11%到24%的病患長期處在慢性疼痛的?況，這除?會影響到他們的生活品質之外，也使得一些病人逐漸出現憂鬱的傾向。多?實驗證實運動能夠減緩急性疼痛的徵?，雖然目前對於??病?經病變性疼痛機轉尚未完全清楚，但一般認為造成?經細胞受氧化壓?(oxidative stress)的傷害與細胞凋亡(apoptosis)的情形為主要原因。因此計畫中將探討使用藥物與運動合併治?第一型與第二型??病之周邊?經病變在?經?為、?經組織學、heat shock protein 72、氧化壓?、抗氧化壓?與?經凋亡之情形作整合性探討。計畫預設為三?計畫，第一?：運動治?第一型與第二型??病大鼠之?經病變；第二?：藥物治?第一型與第二型??病大鼠之?經病變；第三?：藥物合併運動治?第一型與第二型??病大鼠之?經病變。
Diabetes mellitus (DM) is a metabolic disorder resulting from a defect in insulin secretion, insulin action, or both. DM develops due to a diminished production of insulin (in type 1) or resistance to its effects (in type 2 and gestational). The complications of developing diabetics depend on glycemic control, drug (in type 2) and insulin use. Acute complications (hypoglycemia, ketoacidosis, or nonketotic hyperosmolar coma) may occur if the disease is not adequately controlled. Serious long-term complications include retinal damage, cardiovascular disease, chronic renal failure, nerve damage (neuropathy), and microvascular damage. Diabetic painful neuropathy is one of the most common causes of neuropathic pain. Numerous studies indicate that exercise decreases signs of acute pain in nonpathological conditions. Diabetic neuropathies are common among patients with diabetes, affecting 66% of patients with insulin-dependent DM and 59% of patients with noninsulin-dependent DM. Diabetic neuropathic pain is common in injuries of the peripheral, and has a substantial impact on quality of life and mood. The cellular and molecular background underlying neuropathic pain behavior is not clear, but it is widely accepted that both oxidative stress and apoptosis mechanisms could be involved. Therefore, our study will emphasize the effects of exercise or combined drug treatment and exercise training on the neuropathy of type 1 and type 2 diabetic rats, comparing the temporal profiles of neuro-behavior, histology, heat shock protein 72, oxidative stress, and apoptosis. This project will be carried out for three years. In the first year, the exercise training for type 1 and type 2 diabetic neuropathy in rats will be tested. In the second year, drug treatments for type 1 and type 2 diabetic neuropathy in rats will also be evaluated. In the last year, drugs combined with exercises treat type 1 and type 2 diabetic neuropathy in rats. |
