中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/26456
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 29490/55136 (53%)
造訪人次 : 1997834      線上人數 : 213
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於CMUR ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/26456


    題名: 族群分類及/或錯誤資料下對基因-環境/基因-基因交互作用的效應及其調整
    The Effects and Adjustments of Bias Due to Population Stratification And/Or Misclassification in Studies of Gene-Environment/Gene-Gene Interactions
    作者: 鄭光甫(Kuang-Fu Cheng)
    貢獻者: 健康照護學院口腔衛生學系;中國附醫院長室
    日期: 2010-07-31
    上傳時間: 2010-09-08 17:08:11 (UTC+8)
    摘要: Population stratification (PS) and misclassification (MC) of genotype may cause the usual tests in case-control studies producing spurious gene-disease associations. To control for the resulting bias, several powerful approaches have been proposed using unlinked markers. However, the effects of PS and MC of genotype and environmental exposure in studies of gene-environment interactions are still not clear. In my research project, I propose to investigate and control the effects of PS and MC in case-control and case-only studies under general conditions. My first plan is to identify some important conditions under which population stratification and/or misclassification do not introduce bias in case-control or case-only studies of gene-environment interactions. If the effects of PS and MC do exist, another interesting issue is the magnitude of the bias. I propose to study the bounds of the bias and use information related to bounds to control the effect of PS and MC. My final plan is to suggest a new study design so that PS and/or MC can be automatically accounted for. I shall also conduct some simulation studies, with the help from my students and using parameter values from real examples, to compare the power performance of different tests for gene-environment interactions under PS and MC. My preliminary results show that some interesting method do provide valid test for interactions. However, these methods are not powerful, especially when the genetic factors have strong main effects on the risk of disease.
    顯示於類別:[口腔衛生學系] 研究計畫

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    NSC97-2118-M039-001-MY3.pdf464KbAdobe PDF182檢視/開啟


    在CMUR中所有的資料項目都受到原著作權保護.

    TAIR相關文章

     

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋