 |
English
|
正體中文
|
简体中文
|
全文筆數/總筆數 : 29490/55136 (53%)
造訪人次 : 1496671
線上人數 : 354
|
|
|
資料載入中.....
|
請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/2634
|
| 題名: | Anticonvulsive and free radical scavenging actions of two herbs, Uncaria Rhynchophylla (Miq) Jack and Gastrodia elata Bl., in kainic acid-treated rats |
| 作者: | 謝慶良(Ching-Liang Hsieh);唐娜櫻(Nou-Ying Tang);江素瑛(Su-yin Chiang);謝慶竇(Ching-Tou Hsieh);林昭庚(教授，研，董事) |
| 貢獻者: | 中醫學院中西醫結合研究所;中國附醫中醫內科 |
| 關鍵詞: | anticonvulsive;free radical scavenging activity;Uncaria rhynchophylla;Gash-o&a elata;kainic acid |
| 日期: | 1999 |
| 上傳時間: | 2009-08-20 17:45:35 (UTC+8) |
| 摘要: | Uncaria rhynchophylla (Miq.) Jack (UR) and Gasfrodia elafa BI. (GE) are
traditional Chinese herbs that are usually used in combination to treat
convulsive disorders, such as epilepsy, in China. The aim of this study was to
compare the anticonvulsive and free radical scavenging activities of UR alone
and UR in combination with GE in rats. For the in vitro studies, brain tissues
from 6 male Sprague-Dawley (SD) rats were treated with 120 pg/ml kainic
acid (KA), with or without varied concentrations of UR or UR plus GE. For the
in vivo studies, male SD rats (6 per group) received intraperitoneal (i.p.)
injection of KA 12 mglkg to induce epileptic seizures and generation of free
radicals, with or without oral administration of UR 1 g/kg alone or UR 1 g/kg
plus GE 1 g/kg. Epileptic seizures were verified by behavioral observations,
and electroencephalography (EEG) and electromyography (EMG) recordings.
These results showed that UR alone decreased KA-induced lipid peroxide
levels in v&-o, whereas UR plus GE did not produce a greater effect than UR
alone. UR significantly reduced counts of wet dog shakes (WDS), paw tremor
(PT) and facial myoclonia (FM) in KA-treated rats and significantly delayed
the onset time of WDS, from 27 min in the control group to 40 min in the UR
group. UR plus GE did not inhibit seizures more effectively than UR alone,
but did further prolong the onset time of WDS to 63 min (P < 0.05 vs. UR
alone). UR alone reduced the levels of free radicals in viva, as measured by
lipid peroxidation in the brain and luminol-chemiluminescence (CL) counts
and lucigenin-CL counts in the peripheral whole blood, but the combination of
GE and UR did not reduce free radical levels more markedly than UR alone.
In conclusion, our results indicate that UR has anticonvulsive and free radical
scavenging activities, and UR combined with GE exhibit greater inhibition on
the onset time of WDS than UR alone. These findings suggest that the
anticonvulsive effects of UR and GE may be synergistic. However, the
mechanism of interaction between UR and GE remains unknown. |
| 關聯: | LIFE SCIENCES 65(20):2071~2082 |
| 顯示於類別: | [中西醫結合研究所] 期刊論文
|
文件中的檔案:
| 檔案 |
大小 | 格式 | 瀏覽次數 |
|---|
| 58Kb | Unknown | 615 | 檢視/開啟 |
|
在CMUR中所有的資料項目都受到原著作權保護.
|
