馬蘭及芋香林投活性成分之研究

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Title:	馬蘭及芋香林投活性成分之研究 Studies on the Active Constituents of Baphicacanthus cusia and Pandanus odorus
Authors:	張永勳
Contributors:	中國醫藥學院藥學系
Keywords:	馬藍;芋香林投;活性成分;Baphicacanthus cusia;Pandanus odorus;Active constituent
Date:	1999-07
Issue Date:	2010-09-06 23:33:28 (UTC+8)
Abstract:	馬藍(Baphicacanthus cusia (Nees) Bremek.)為爵床科(Acanthaceae)植物,具有抗發炎、抗菌及抗癌等活性,馬藍根部之抽出物在細胞毒性方面對p-388具有很強的活性, 因此本研究以細胞毒性當活性引導分離指標,進行成分分離因此在本研究中,便以其抗細胞毒性作為活性指標,進行化學成分之分離,共分離得到八個化合物,分別為Lupeol (H-1),Stigmasterol和.beta.-sitosterol混合物 (H-2),Betulin (H-3),Indigo (C-1), Indirubin (C-2),2-Benzoxazolinone (E-1)及2-Hydroxy-1,4-benzoxazin-3-one (E-2),4-Hydroxy-3-methoxy benzoic acid (E-3)。芋香林投 (Pandanus odorus Ridl.)為露兜樹科(Pandanaceae)植物,一般當做食物或食物矯味用,另外也有降低血糖、保護肝臟、抑制腫瘤惡化等民間醫療用法。芋香林投葉部之甲醇抽出物在細胞毒性方面對p-388及A-549具有很強的活性,故本實驗以細胞毒性當活性引導分離指標,進行成分分離。本研究分離鑑定出五個化合物,分別為.beta.-sitosterol and stigmasterol (NH-1)、.beta.-sitosterol-3-O-.beta.-D-glucoside and stigmasterol-3-O-.beta.-D-glucoside (NH-2)、methylsuccic anhydride (NH-3)、1,3-dimethyl-pyrrolidine-2,5-dione (NH-4)、p-hydroxycinnamic acid (NH-5);在保肝活性試驗方面則對四氯化碳誘導之急性肝毒性具有保護作用。 The plant Baphicacanthus cusia (Nees) Bremek. of Acanthaceae family has been used in traditional Chinese medicine for a long time. The plant has been used as anti-inflammatory, antibacterial and anti-carcinogenic agent. The extract of Baphicacanthus cusia root showed strong inhibitory effect on tumor cell lines such as p-388. Based on the cytotoxicity guided chemical fractionation, eight compounds were isolated: Lupeol (H-1), mixture of Stigmasterol and .beta.-sitosterol (H-2), Betulin (H-3), Indigo (C-1), Indirubin (C-2), 2-Benzoxazolinone (E-1), 2-Hydroxy-1,4-benzoxazin-3-one (E-2), and 4-Hydroxy-3-methoxy benzoic acid (E-3). Panadus odorus Ridl. is one of the species of Pandanaceae family. It has been used as foods, flavoring or as a herb medicine effective in lowering blood sugar level, liver protection and inhibiting tumor growth. The methanolic extract of the leaves of Pandanus odorus Ridl. showed strong inhibitory effect on tumor cell lines such as P-388 and A-549. Based on the cytotoxicity guided chemical fractionation, five compounds were isolated: mixture of .beta.-sitosterol and stigmasterol (NH-1), .beta.-sitosterol-3-O-.beta.-D-glucoside and stigmasterol-3-O-.beta.-D-glucoside (NH-2), methylsuccic anhydride (NH-3), 1,3-dimethyl-pyrrolidine-2,5-dione (NH-4), p-hydroxycinnamic acid (NH-5). The methanol extract of Pandanus odorus showed strong protective effect against carbon tetrachloride induced liver toxicity.
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