抗老化中藥療效評估之基礎研究---中藥中黃酮類抗氧化成分之吸收與代謝

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Title:	抗老化中藥療效評估之基礎研究---中藥中黃酮類抗氧化成分之吸收與代謝 Absorption and Metabolism of Antioxidant Flavonoids in Chinese Herbs
Authors:	李珮端;徐素蘭
Contributors:	中國醫藥學院
Keywords:	抗氧化劑;黃酮類;吸收;代謝;Antioxidants;Flavonoids;Absorption;Metabolism
Date:	1999-06
Issue Date:	2010-09-06 23:25:27 (UTC+8)
Abstract:	自由基學說為老化的重要理論之一。許多黃酮類具清除自由基及抗氧化劑之活性。有些中藥材富含黃酮類，黃酮類若能吸收進入體內，應可預防心血管疾病、癌症、白內障等老化的現象。本研究針對富含黃酮類成分的中藥如枳殼、化橘紅、陳皮及槐花米等進行活體實驗，以高效液相層析法定量血液或尿液中Naringin、 Hesperidin及Rutin之代謝物，以了解這些抗氧化劑之吸收及代謝。藥物動力學參數採WINNONLIN軟體計算。結果顯示黃酮類配醣體於腸道中為細菌水解成非醣體後方能吸收。當其非醣體首度經過腸壁及肝臟時，有明顯的代謝發生，循環於血中的多為結合態代謝物。血清中代謝物濃度經時變化之曲線顯示有明顯的腸肝循環現象。此三種黃酮類配醣體的吸收均頗低。我們建議值得進一步進行此三種黃酮類配醣體之前處方設計，以提高其吸收及藥效。 Free radical damage was believed to be an important cause of aging. Various flavonoids were shown to be free radical scavengers and antioxidants. The wide distribution of flavonoids in plant kingdom prompts us to search for anti-aging agents from Chinese herbs. Naringin, hesperidin and rutin are flavonoid glycosides which are major constituents of herbs, e. g. zhiquor, chenpee and huaihua. This study investigated the absorption and metabolism of those three glycosides and their aglycones as pure compounds and from herbal decoctions. HPLC method was used to assay the serum and urine concentrations of the parent compounds and their metabolites. Our results indicated that the flavonoid glycosides were hydrolyzed by microflora in gut lumen into aglycones which is the absorbable form. During the first pass through gut wall, conjugation metabolism occurred appreciably. The pharmacokinetic parameters were calculated by using WINNONLIN. The absorption of these three flavonoids glycosides was quite low, especially for hesperidin. Most of the absorbed flavonoids circulate as glucuronides in the body. There was significant enterohepatic recycling. We suggested that preformulation study of these flavonoid glycosides were needed in order to enhance their absorption and efficacy.
Appears in Collections:	[China Medical University] Research reports

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