中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/25715
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    题名: 副甲狀腺素治療對自發性高血壓大白鼠所引發骨質流失的研究
    Parathyroid Hormone Restores Bone Mass for Osteopenia in the Spontaneously Hypertensive Rat
    作者: 王天美
    贡献者: 中國醫藥學院
    关键词: 副甲狀腺素;骨質流失;骨質疏鬆症;骨折;自發性高血壓;Parathyroid hormone (PTH);Osteopenia;Osteoporosis;Fracture;Spontaneous hypertension
    日期: 1998-07
    上传时间: 2010-09-06 23:24:55 (UTC+8)
    摘要: Daily subcutaneous injection of graded
    doses of 0, 4, 8, or 16Ðg / 100g hPTH 1-34
    of 19-week-old male spontaneously hypertensive
    rat (SHR) of five rats in each group for
    14 days were done. The 21-week-old SHR
    exhibited a significant lower metaphyseal
    trabecular bone volume osteopenia
    accompanied by poor trabecular architecture
    than in Wistar-Kyoto (WKY) rats were
    observed in the study. The preservation of
    trabecular bone volume in the PTH-treated
    rats was associated with an increase in
    number of osteoblasts, bone surface extent of
    osteoblasts, double labelled bone surface,
    mineral apposition rate and trabecular
    thickness. Trabecular number remained
    comparable to control. Measurements of
    resorption such as percent eroded surface and
    numbers of osteoclasts also remained
    comparable to control values. These dual
    effects increase the bone formation rate and in
    the absence of significant resorption, result in
    a net increase in bone mass. The above
    findings of histomorphometric data support
    the hypothesis that the PTH increase bone
    mass by specific effects on osteoblast
    activation and function.
    显示于类别:[中國醫藥大學] 研究計畫

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