Disease association of the CD103 polymorphisms in Taiwan Chinese Graves’ ophthalmopathy patients.

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Title:	Disease association of the CD103 polymorphisms in Taiwan Chinese Graves’ ophthalmopathy patients.
Authors:	呂郁蕙(Yu-Huei Liu);陳榮興(Rong-Hsing Chen);陳汶吉(Chen, Wen-Chi);蔡育勳(Yuhsin Tsai);萬磊(Lei Wan);蔡輔仁(Fuu-Jen Tsai)
Contributors:	中醫學系中醫內科學科;中國附醫小兒遺傳科
Keywords:	CD103 polymorphisms
Date:	2010-08
Issue Date:	2010-09-06 13:46:30 (UTC+8)
Abstract:	Objective To evaluate whether variations in the CD103 gene could be associated with Graves' ophthalmopathy (GO) in patients with Graves' disease. Design Case-control study. Participants A total of 484 Chinese patients with Graves' disease in Taiwan, including 203 patients with GO and 281 patients without GO, were enrolled. Methods Five single nucleotide polymorphisms (SNPs) in CD103 were genotyped using an assay-on-demand allelic discrimination assay and detection system according to the manufacturer's instructions. Main Outcome Measures Association of SNPs in CD103 with the development of GO. Results The CD103 SNP rs11652878 was associated with GO, which may decrease the risk of GO by 1.57-fold (P = 0.029). The Ht5-GCGCG haplotype, composed of 5 SNPs in the CD103 gene (rs1716, rs3744679, rs11652878, rs16953477, and rs9905739), were protective haplotypes (P = 0.010). Moreover, the heterozygous genotype (Ht5/non-Ht5) was correlated with a reduced risk of GO and high grades of goiter as compared with the non-Ht5/non-Ht5 genotype (P = 0.006 and P = 0.048, respectively). Logistic analysis confirmed the contribution of CD103 rs11652878 to the protection of GO. Conclusions These data suggest that patients with Graves' disease in the presence of the G allele of SNP rs11652878, especially Ht5-GCGCG, in CD103 are less susceptible toward the development of GO.
Relation:	OPHTHALMOLOGY 117(8):1645~1651
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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