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    Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/25675


    Title: SMD-2合併放射線及化學治療頭頸部癌病患對尿中微量元素Cu/Zn及Cu/Se之比值與生活品質及中醫證型變化之評估
    Evaluation of the effect of SMD-2 on the human urine trace elements (Cu/Zn and Cu/Se), quality of life and TCM differentiation of syndrome in head and neck cancer patients receiving the radiotherapy and chemotherapy
    Authors: 賴東淵;陳志毅;梁基安;楊世能;謝慶良
    Contributors: 中國醫藥大學學士後中醫系
    Keywords: 癌症患者;生活品質;尿液;微量元素;Cu/Zn及Cu/Se比值;Cancer patients;Quality of life;Urine;Trace element;Cu/Zn and Cu/Se ratios
    Date: 2009-12
    Issue Date: 2010-09-05 16:05:37 (UTC+8)
    Abstract: 放射治療是癌症治療中佔有重要的角色，許多早期癌症接受根除性放射線照射，5年存活率高達90%；許多晚期癌症接受姑息性放射線照射，仍可緩解症狀，延長生命。然而，放射線治療也會導致副作用。由前導研究結果，放射治療癌症患者接受SMD-2輔助性治療，發現體重增加及4個指標（食慾、口乾、體力與精神）改善，及三黃瀉心湯對癌症病人尿中微量元素（Cu/Zn與Cu/Se）比值與生活品質成反比，啟發我們進一步探討其作用機轉。本研究SMD-2對放射線治療與化學治療頭頸部癌病患，研究癌症放射治療中患者之中醫體質特性，進行中醫辨證分型，分析癌症病人體質中醫證型之分佈，並從事病患尿中微量元素（Cu/Zn與Cu/Se）比值與生活品質之臨床評估。關鍵詞：癌症患者、生活品質、尿液、微量元素、Cu/Zn及Cu/Se比值

    Radiotherapy plays an important role in cancer therapy. Most of the early stages of cancer with curative radiotherapy can achieve up to 90% of a 5-year survival rate. Even for patients at late stage, their symptoms also can be relieved. Every radiotherapy and chemotherapy has the potential to cause harm and produce toxicity such as weakness, tired, anorexia nervosa, dry mouth. With the early research, we find that SMD-2 can relieve the symptoms of weakness, tired, anorexia nervosa, dry mouth. Furthermore, we have also found out that the cancer patients who are receiving the therapy of San-Huang-Hsien-Hsin-Tang, shows an inverse ratios between the quality of life and trace elements Cu/Zn and Cu/Se in urine. So we are interested to probe into the mechanism of SMD-2 on this research. The present study is to evaluate the effects of SMD-2 in the head & neck cancer patients receiving the radiotherapy and chemotherapy, especially examinate their characteristic of TCM constitution, prosecute the TCM differentiation of syndrome, and analyze the distribution of TCM syndrome differentiation in cancer patients. In addition, we are going to assess the clinical evaluation among the ratios of trace elements Cu/Zn and Cu/Se in urine during treatment, and to estimate the quality of life (EORTC: QLQ-C30) during the period of radiotherapy and chemotherapy on the basis of Chinese Medicine Theory. keywords: cancer patients, quality of life, urine, trace element, Cu/Zn and Cu/Se ratios
    Appears in Collections:[School of Post-Baccalaureate Chinese Medicine] Research reports

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