蘭嶼肉桂之活性組成分析鑑定與生物活性評估

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Title:	蘭嶼肉桂之活性組成分析鑑定與生物活性評估
Other Titles:	Analysis of Bioactive Constituents from Cinnamomum Kotoense and Their Bioactivity Evaluation
Authors:	趙國評
Contributors:	中國醫藥大學藥用化妝品學系
Keywords:	蘭嶼肉桂;葉部;木材;精油;萃出物;抗氧化;抗發炎;抗腫瘤;生物活性;Cinnamomum kotoense;leaf;wood;essential oil;bioactivity,antioxidant;anti-inflammatory;antitumor
Date:	2009-07
Issue Date:	2010-09-05 15:48:01 (UTC+8)
Abstract:	蘭嶼肉桂是生長於本省蘭嶼特有的肉桂樹種之一，屬於臺灣特有種。近年來本省特有之台灣土肉桂精油的生物活性開發已屢被學者研究，並發表於世界重要學術期刊，顯示本土性特有植物精油之高度開發潛力。依據目前學者已發表的相關文獻顯示，臺灣土肉桂葉子精油具有良好之抗真菌、抗.、抗白蟻、抗細菌與抗蚊幼蟲之活性，肯定其利用價值。但相對於蘭嶼肉桂葉部與木材之精油及其抽出成分而言，卻無類似之研究報告，故本研究計畫之目的為萃取與分離蘭嶼肉桂葉部與木材之精油以及樹葉和木材之抽出成分，評估其生物活性；包括抗氧化、抗發炎與抗腫瘤等生物活性，同時鑑定具生物活性成分之化學結構。本計畫將以水蒸餾法抽取蘭嶼土肉桂葉部與木材之精油，以及分別以熱水和溶劑萃取蘭嶼肉桂之葉部和木材之抽出成分，續以不同極性之溶劑萃取區分為各分離部，並進行各項生物活性試驗，同時利用氣相層析儀分析精油之主要化學組成。此外具有生物活性之葉子和木材抽出成分之各分離部，將先以管柱層析細分離後，再接以液相層析儀純化其主要成分，再進行單一組成之生物活性分析。本計畫如能順利完成，將可具體瞭解蘭嶼肉桂葉部與木材之精油及其抽出物的生物活性特質，除擴大本土林產產物開發利用範圍之外，同時可開發具有生物活性之成分應用於保健醫藥等領域。 Cinnamomum kotoense Kanehiraet Sasaki is one of the indigenous and the peculiar hardwood species to Taiwan. There were many studies which investigated the bioactivity of the leaf essential oils from C. osmophloeum, and had been published in the important academic journals in recently. It was presented that developing the essential oils from the plant would have the highly potential. According these published studies, the essential oils from C. osmophloeum indeed has a good antifungi, antimitic, antitermites, antibacterial and antimosquito larva bioactivities. It was undoubtedly that the essential oils of leaf and wood from C. osmophloeum have highly developed potential but we were not familiar to C. kotoense in related studies. The aim of this study is evaluated the bioactivities of the essential oils and extracts of leaf and wood from C. osmophloeum which including the antioxidant, anti-inflammatory and antitumor bioactivities. In the meanwhile the composition of these essential oils would be analyzed. This project will extract the essential oil and extracts of leaf and wood from C. osmophloeum by water distillation method and solvents following assay their bioactivities and employ the GC-MS for their composition analysis. In addition, we will purify the major compounds from the essential oil and extracts by liquid chromatoraphy, after that the bioactivities of these major compounds were analyzed. When this study is finished successfully, it is comprehended that bioactive characteristics of essential oils and extracts of leaf and wood from C. osmophloeum. Not only enlarge the ranges of forestry products utilization but developing these bioactive materials in medicines.
Appears in Collections:	[Graduate Institute of Cosmeceutics] Research reports

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