| 摘要: | Objective: The aim of this study was to examine whether the disease-specific quality of life
measures are independent predictors of mortality in patients with type 2 diabetes.
Methods: A cohort of 420 diabetic patients were recruited from the outpatient clinic of a medical
center. At baseline, the disease-specific measure of the Diabetes Impact Measurement Scales
(DIMS), and clinical and biological marker variables were measured. DIMS domains included
symptoms, diabetes-related morale, social role fulfillment, and well-being. Complications consisted
of stroke, heart disease, visual impairment, amputations, kidney disease, cognitive impairment, and
incontinence. Mortality data were collected from the national mortality register using personal
identification numbers. Multivariate Cox's proportional hazards models were used.
Results: The overall mortality was 10.9%. The DIMS scales of symptoms and well-being, and the
total score were significantly associated with mortality, independent of age, gender, and
complications. When the scales of DIMS were simultaneously considered, only symptom and social
role fulfillment of the DIMS exerted a significant effect on mortality. Patients in the categories of the
2nd and 3rd quartile (worse status) had significantly increased risk compared to those in the
category of the 4th quartile (best status) (for the symptom scale, RR: 13.10, 95% confidence
interval [CI]: 2.75-62.50; RR: 5.49, 95% CI: 1.50-20.09, respectively; for the social role fulfillment
scale, RR: 6.18, 95% CI: 1.10-34.87; RR:6.53, 95% CI: 1.40-30.57).
Conclusions: Our data suggest that the unique contribution of the HRQOL to mortality was
independent of more objective health measures, such as diabetes control and complications. |
