資料載入中.....
|
請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/24975
|
| 題名: | Neolignans, Coumarinolignan, Lignan Derivatives, and a Chromene: Anti-inflammatory Constituents from Zanthoxylum avicennae |
| 作者: | Tzu-Ying Wang (王姿穎), Tsong-Long Hwang (黃聰龍), Jih-Jung Chen (陳日榮) |
| 貢獻者: | Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
Graduate Institute of Pharmaceutical Chemistry, College of Pharmacy, China Medical University, Taichung 404, Taiwan |
| 關鍵詞: | Zanthoxylum avicennae, Rutaceae, neolignans, coumarinolignan, lignan derivatives, chromene, anti-inflammatory activity |
| 日期: | 2008-11-22 |
| 上傳時間: | 2010-06-22 18:29:14 (UTC+8) |
| 摘要: | Zanthoxylum avicennae (Lam.) DC (Rutaceae) is an evergreen shrub distributed in Vietnam, Philippines, southern China, and Taiwan. A decoction of its stems is used as a stomach tonic and as a counter-poison to snake bite. Investigation on EtOAc-soluble fraction of the stem wood of Z. avicennae has led to the isolation of four new neolignans, (7′S,8′S)-bilagrewin (1), (7′S,8′S)-5-demethoxybilagrewin (2), (7′S,8′S)-5-O-demethyl-4′-O-methylbilagrewin (3), and (7′S,8′S)-nocomtal (4), a new coumarinolignan, (7′S,8′S)-4′-O-methylcleomiscosin D (5), two new lignan derivatives, (+)-9′-O-(Z)-feruloyl-5,5′-dimethoxylariciresinol (6) and (+)-9′-O-(E)-feruloyl-5,5′-dimethoxylariciresinol (7), and a new chromene, (E)-3-(2,2- dimethyl-2H-chromen-6-yl)prop-2-enal (8), together with 19 known compounds. The structures of these new compounds were determined through in-depth spectroscopic and MS analyses. Among the isolated compounds, (7′S, 8′S)-4′-O-methylcleomiscosin D (5), cleomiscosin D (9), skimmianine (18), robustine (19), and integrifoliolin (23) exhibited inhibition (IC50 ≤ 18.19 M) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L- phenylalanine/cytochalasin B (FMLP/CB). In addition, skimmianine (18) inhibited FMLP/CB-induced elastase release with an IC50 value of 19.15 ± 0.66 M. |
| 關聯: | 九十七年度台灣藥學會與臺灣臨床藥學會聯合年會 |
| 顯示於類別: | [藥物化學研究所] 會議論文
|
在CMUR中所有的資料項目都受到原著作權保護.
|
