Influence of Interleukin 18 Promoter Polymorphisms in Susceptibility to Kawasaki Disease in Taiwan

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Title:	Influence of Interleukin 18 Promoter Polymorphisms in Susceptibility to Kawasaki Disease in Taiwan
Authors:	薛凱中(Kai-Chung Hsueh);林應如(Ying-Ju Lin);張正成(Jeng-Sheng Chang);萬磊(Lei Wan);蔡育勳(Yuhsin Tsai);蔡長海(Chang-Hai Tsai);蔡輔仁(Fuu-Jen Tsai)*
Contributors:	中國附醫兒童醫學中心小兒過敏免疫風濕科
Keywords:	INTERLEUKIN 18;KAWASAKI DISEASE;PROMOTER;POLYMORPHISM
Date:	2008-02
Issue Date:	2009-08-20 17:31:14 (UTC+8)
Abstract:	Objective Proinflammatory cytokines such as interferon-γ (IFN-γ) play an important role in the pathogenesis of Kawasaki disease (KD). Interleukin 18 (IL-18) plays a pivotal role in the T helper 1 (Th1)-type response, principally owing to its ability to induce IFN-γ production. We assessed potential associations between functional IL-18 gene promoter polymorphisms and susceptibility to KD, in addition to clinical features of KD in individuals from Taiwan. Methods One hundred forty-six patients with KD and 136 ethnically matched controls from the same geographic area were genotyped for IL-18 −656T/G, −607A/C, and −137C/G promoter polymorphisms. Results No significant differences in allele and genotype frequencies were found between KD patients and controls for any of the IL-18 polymorphisms investigated. When we compared the overall distribution of haplotype frequencies between KD patients and controls, a significant difference was observed (p < 0.0001). In addition, the frequency of the GCG haplotype was significantly higher (p = 0.00001, pc = 0.00004; OR 20.8, 95% CI 3.05–142.3), whereas the frequency of the TAG haplotype was significantly lower in KD patients compared with controls (p = 0.0001, pc = 0.0004; OR 0.35, 95% CI 0.19–0.61). No significant associations were found for comparisons of KD patients to those with and without coronary artery lesions. Conclusion Our results suggest a potential implication of IL-18 promoter polymorphisms in susceptibility to KD in Taiwan.
Relation:	JOURNAL OF RHEUMATOLOGY35(7):1408~1413
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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