Association of XRCC4 codon 247 polymorphism with oral cancer susceptibility in Taiwan.

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/2480

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题名:	Association of XRCC4 codon 247 polymorphism with oral cancer susceptibility in Taiwan.
作者:	曾憲彰(Hsien-Chang Tseng);蔡銘修(Ming-Hsui Tsai);邱昌芳(Chang-Fang Chiu);王仲興(Chung-Hsing Wang);張乃文(Nai-Wen Chang);黃志揚(Chih-Yang Huang);(CHIA-WEN TSAI);梁雲(Shiu-Yun Liang);(CHENG-LI WANG);包大靝(Da-Tian Bau)*
贡献者:	中國附醫耳鼻喉部
关键词:	XRCC4;polymorphism;oral cancer;carcinogenesis
日期:	2008-05
上传时间:	2009-08-20 17:31:09 (UTC+8)
摘要:	Background: The DNA repair gene XRCC4, an important caretaker of overall genome stability, is thought to play a major role in the development of human carcinogenesis. However, the association of the polymorphic variants of XRCC4 with oral cancer susceptibility has never been reported. Materials and Methods: In this hospital-based case-control study, the association of XRCC4 codon 247 (rs3734091), G-1394T (rs6869366), intron 7 (rs28360317) and intron 7 (rs1805377) polymorphisms with oral cancer risk in a Central Taiwanese population was investigated. In total, 318 patients with oral cancer and 318 age- and gender-matched healthy controls recruited from the China Medical Hospital in Central Taiwan were genotyped. Results: A significantly different distribution was found in the frequency of the XRCC4 codon 247 genotype, but not the XRCC4 G-1394T or intron 7 genotypes, between the oral cancer and control groups. A/C heterozygosity at XRCC4 codon 247 conferred a significant (2.04-fold) increased risk of oral cancer. As for XRCC4 G-1394T and intron 7 polymorphisms, there was no difference in distribution between the oral cancer and control groups. Gene-environment interactions with smoking, but not with betel quid chewing or alcohol consumption, were significant for XRCC4 codon 247 polymorphism. The XRCC4 codon 247 A/C genotype in association with smoking conferred an increased risk of 3.44 (95% confidence interval = 1.24-9.60) for oral cancer. Conclusion: Our results provide the first evidence that the heterozygous A allele of the XRCC4 codon 247 may be associated with the development of oral cancer and may be a novel useful marker for primary prevention and anticancer intervention.
關聯:	ANTICANCER RESEARCH28(3):1687~1692
显示于类别:	[台中附設醫院] 期刊論文

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