Association Between Pulse Pressure and 30-Month All-Cause Mortality in Peritoneal Dialysis Patients

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Title:	Association Between Pulse Pressure and 30-Month All-Cause Mortality in Peritoneal Dialysis Patients
Authors:	劉炯勳(Jiung-Hsiun Liu);陳清助(Ching-Chu Chen);王舒民(Shu-Ming Wang);周哲毅(Che-Yi Chou);劉耀隆(Yao-Lung Liu);郭慧亮(Huey-Liang kuo);林信宏(Hsin-Hung Lin);王怡寬(I-Kuan Wang);楊雅斐(Ya-Fei Yang)*;黃秋錦(Chiu-Ching Huang)
Contributors:	中國附醫內科部腎臟科
Date:	2008-12
Issue Date:	2009-08-20 17:30:42 (UTC+8)
Abstract:	Background Pulse pressure (PP) is an independent predictor of cardiovascular and/or all-cause mortality in patients with underlying cardiovascular disease. We examined whether PP can be used to predict overall mortality in peritoneal dialysis (PD) patients. Methods We studied 153 PD patients (mean age, 54.5 plusminus 14.2 years) with end-stage renal disease. PP was measured monthly for 3 months. At the time of the third PP measurement, baseline demographic, clinical, biochemical, and dialysis data were collected. Patients were stratified into tertiles according to average PP, and the relationship between blood pressure parameters and all-cause mortality over a 30-month follow-up was assessed using Cox regression. Results There were 27 deaths; three deaths occurred after the change to hemodialysis (HD) (subjects died within 3 months after HD) and were counted as events during survival analysis. The overall 30-month survival (Kaplan–Meier curves) times were significantly different among the tertiles of PP (P < 0.05). Increased PP was significantly associated with overall mortality regardless of adjustment for systolic blood pressure (SBP) or diastolic blood pressure (DBP). Conclusions PP may be the most consistent blood pressure indicator of mortality risk. All-cause mortality events in PD patients are more related to pulsatile stress caused by the stiffness of large arteries during systole (reflected in a rise of PP) than to steady-state stress stemming from resistance during diastole (reflected in a rise of SBP and DBP).
Relation:	AMERICAN JOURNAL OF HYPERTENSION21(12):1318~1323
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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