台灣產地蜈蚣之化學成分研究; Studies on the Chemical Constituents of the Torenia concolor Lindley

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Title:	台灣產地蜈蚣之化學成分研究;Studies on the Chemical Constituents of the Torenia concolor Lindley
Authors:	丁治文;chih-wen Ding
Contributors:	中國醫藥學院藥物化學研究所
Keywords:	地蜈蚣;Torenia concolor Lindley
Date:	1991
Issue Date:	2009-12-03 10:03:51 (UTC+8)
Abstract:	台灣產藥用植物地蜈蚣 (Torenia concolor Lindley) 為玄參科 (Scrophulariaceae) 植物，一名倒地蜈蚣、釘地蜈蚣。台灣民間用其全草，具有清熱，解毒，散瘀解毒，生肌止痛。用於癰瘡，疔腫，無名腫毒，跌打內傷，中暑，為常用之台灣民間藥。經由國家衛生研究院MTS細胞毒殺活性試驗，發現地蜈蚣萃取物中乙酸乙酯層和正丁醇層對於NUGC（人類胃癌細胞）具有抑制活性。地蜈蚣之乾燥全草之甲醇粗抽物經分離及結構鑑定，化學成分部分，自地蜈蚣全草分離出之成分有lupeol (C-1), β-sitosterol and stigmasterol (C-2), betulin (C-3), betulinic acid (C-4), oleanolic acid (C-5), maslinic acid (C-6), alphitolic acid (C-7), 3-epimaslinic acid (C-8), augustic acid (C-9), β-sitosterol -3-O-β-D-glucoside (C-10)等成分。以上成分皆首次在本植物中分離得到。; Torenia concolor Lindley is a native Scrophulariaceae plant of Taiwan. In Folk medicine, it is used to remove blood stasis, reduce inflammation and clear away heat evil. Our preliminary tests showed that the ethylacetate extract and n-butanol extract of Torenia concolor Lindley exhibited cytotoxicity against NUGC cell lines. The bioactive compounds would be isolated and the chemical structures be elucidated. The methanolic extract of the whole herb was partitioned and separated by chromatographic methods. Ten compounds were isolated and identified. Their structure were determined on the basis of spectral evidence as well as direct comparison with authentic samples. These compounds included lupeol (C-1), β-sitosterol and stigmasterol (C-2), betulin (C-3), betulinic acid (C-4), oleanolic acid (C-5), maslinic acid (C-6), alphitolic acid (C-7), 3-epimaslinic acid (C-8), augustic acid (C-9) andβ-sitosterol -3-O-β-D-glucoside (C-10). These compounds were first isolated from this plant and their structures were determined by spectroscopic methods.
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