Uremic Pruritus, Cytokines, and Polymethylmethacrylate Artificial Kidney

CMUR > China Medical University Hospital > Jurnal articles > Item 310903500/2412

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/2412

Title:	Uremic Pruritus, Cytokines, and Polymethylmethacrylate Artificial Kidney
Authors:	林信宏(Hsin-Hung Lin);劉耀隆(Yao-Lung Liu);劉炯勳(Jiung-Hsiun Liu);周哲毅(Che-Yi Chou);楊雅斐(Ya-Fei Yang);郭慧亮(Huey-Liang kuo);黃秋錦(Chiu-Ching Huang)*
Contributors:	中國附醫內科部腎臟科 Uremic pruritus;Hemodialysis;Cytokine;Artificial kidney
Date:	2008-06
Issue Date:	2009-08-20 17:30:36 (UTC+8)
Abstract:	Abstract: Uremic pruritus is one of the common complications in long-term dialysis patients. Recently, researchers reported that immunohypothesis with high serum level of cytokines could be the cause of uremic pruritus. Polymethylmethacrylate (PMMA) artificial kidney (AK) has been reported to adsorb more serum cytokines than other high-flux AKs. In July 2006, 30 patients with severe uremic pruritus from 300 chronic hemodialysis (HD) patients in a single center entered this prospective study. Their dialyzers were changed to PMMA AK for 4 weeks. The severity of pruritus was evaluated every week using the results of a questionnaire (pruritus score). Laboratory assays including predialysis serum blood urea nitrogen (BUN), creatinine, β2-microglobulin (β2M), calcium, phosphate, intact parathyroid hormone (iPTH), total CO2, ferritin, hematocrit, high-sensitivity C-reactive protein (hsCRP), IL-1β, IL-2, IL-6, IL-18, tumor necrosis factor-α (TNF-α), Kt/V, and β2M clearance were measured before and at the end of 4 weeks of PMMA AK use. PMMA AK was effective in reducing the pruritus score from 23.46 ± 11.94 to 7.38 ± 6.42 (P < 0.001). The effect of uremic pruritus relief appeared after 1 week of PMMA AK use. There were no significant differences in the laboratory assay results including predialysis serum BUN, Cr, β2M, calcium, phosphate, calcium–phosphate product, iPTH, total CO2, ferritin, hematocrit, hsCRP, IL-1β, IL-2, IL-6, IL-18, TNF-α, Kt/V, and β2M clearance. The mechanism for the beneficial effect of PMMA AK on uremic pruritus remains to be determined. PMMA AK may be a useful adjuvant therapy in chronic HD patients with severe uremic pruritus.
Relation:	ARTIFICIAL ORGANS32(6):468~472
Appears in Collections:	[China Medical University Hospital] Jurnal articles

Files in This Item:

File	Size	Format
	0Kb	Unknown	557	View/Open

Loading...