  酸類緣物對於人類前骨髓性血癌細胞 ( HL-60 cells ); Effect of Indole-3-acetic acid Analogs on Differentiation

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题名:	  酸類緣物對於人類前骨髓性血癌細胞 ( HL-60 cells );Effect of Indole-3-acetic acid Analogs on Differentiation
作者:	陳俊仁;Chen Chun Jen
贡献者:	中國醫藥學院藥物化學研究所
关键词:	細胞分化劑;-3-醋酸類緣物;全反式維甲酸;人類前骨髓性白血病;細胞週期;cell differentiation agents;Indole-3-acetic acid ( IAA ) analogs;all-trans retinoic acid ( ATRA );acute promyelocytic leukemia ( APL );cell cycle;HL-60 cell;NBT
日期:	1990
上传时间:	2009-12-03 09:30:38 (UTC+8)
摘要:	為了尋求新型的細胞分化劑，著者針對一系列??-3-醋酸 ( IAA ) 類緣物進行分化作用與抑制增殖作用之篩選工作。發現化合物IAA-Ile及IAA-Phe其二者對促進全反式維甲酸分化活性之效果最為顯著。於是進一步地以其對HL-60細胞週期之影響及細胞表面抗原表現來探討其初步作用機轉。當化合物IAA-Ile及IAA-Phe與全反式維甲酸併用時，其對細胞週期及細胞表面抗原表現影響的結果顯示與全反式維甲酸於誘導細胞分化時產生的結果相似。綜合本研究結果：化合物IAA-Ile及IAA-Phe併用全反式維甲酸使用於人類前骨髓性白血病的分化療法上應有不錯的助益。; In order to develop the novel cell differentiation agents, a series of Indole-3-acetic acid ( IAA ) analogs were screened for their differentiation and antiproliferation activities of HL-60 cells. Compounds, IAA-Ile and IAA-Phe were found to be the most effective to potentiate the induction of differentiation by all-trans retinoic acid ( ATRA ). Therefore the further studies were carried out to evaluate their effects on the cell cycle and cell surface antigen expression of HL-60 cells. When combined with ATRA, compounds IAA-Ile and IAA-Phe were found to affect the cell cycle and cell surface antigen expression in the same manner as ATRA. This finding suggest that IAA-Ile and IAA-Phe when administered together with ATRA, may have beneficial therapeutic effects in the treatment of acute promyelocytic leukemia ( APL ).
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