中藥離子導入與雷公藤的文獻分析暨雷公藤用離子導入治療僵直性脊椎炎的臨床療效評估; Analysis for the Literatures of Iontophoresis, Radix Tripterygii Wilfordii and Effect Evaluation of the Tripterygium Solution on AS Clinical Trials

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题名:	中藥離子導入與雷公藤的文獻分析暨雷公藤用離子導入治療僵直性脊椎炎的臨床療效評估;Analysis for the Literatures of Iontophoresis, Radix Tripterygii Wilfordii and Effect Evaluation of the Tripterygium Solution on AS Clinical Trials
作者:	郭文華;Kuo, Wen-hua
贡献者:	中國醫藥學院中西醫結合研究所
关键词:	雷公藤;藥物離子導入;典籍考證;針剌穴位;僵直性脊椎炎;Iontophoresis;TCM Literatures;Acupuncture;Tripterygii;Akylosin spodylosis
日期:	1991
上传时间:	2009-12-01 20:14:40 (UTC+8)
摘要:	二十一世紀是生物科技的年代。從皮膚透入的局部外用藥預測將會有突飛猛進的發展。而藥物離子導入的技術正是重要發展的方法之一。傳統中藥誓將也可能搭上這般列車，而進入另一番新境界。是故本論文首先綜訴藥物離子導入技術之基礎實驗，各方面的近代研究進展與未來的發展方向。次段接著將中藥離子導入的所有研究報告，做一個期刊論文的電腦分析。資料整合是從1960年起至2001年底，總共匯集有492篇論文。然後從治療的主治病例、報告年月、研究機構、發表作者、離子導入的用藥與用方。一一做分析，以顯示出中藥離子導入的臨床醫學發展現況。接著介紹雷公藤的中醫典籍探研、現代藥理與臨床應用。以及僵直性脊椎炎的傳統中醫與現代醫學觀點。最後階段，我們試著使用中藥雷公藤水煎劑，以中藥電離子導入的技術，配合著針灸，應用於僵直性脊椎炎的背痛問題。統計分析醫院臨床研究的成果，達到本所中西結合的目標。本次臨床研究是匯集25位僵直性脊椎炎背痛發作的病患，分AB兩組，A組12人，B13人。每人以29天為治療研究期。AB兩組的差別在於A組是第一週使用雷公藤作離子導入，第三週用注射用蒸餾水作電離子導入，第二、四週則只有針灸，沒有任何的藥物離子導入。B組治療是第一週與第三週對調。第一週用蒸餾水作離子導入，而第三週才用雷公藤，其他一切皆同。我們是在每天早上治療前填寫疼痛指數與副作用的調查表，並於每週一治療前做常規血液、生化檢查。比較蒸餾水離子導入加針灸與雷藤離子導入加針灸的臨床效果，顯示雷公藤離子導入加針灸的治療，不但有鎮痛作用，還有降低CRP的消炎作用，而且消炎鎮痛作用能延長超過72小時以上。相反地，使用蒸餾水與單用針灸期間，則只有短期的鎮痛(<72小時內)，沒有明顯的消炎作用。關鍵詞：雷公藤、藥物離子導入、典籍考證、針剌穴位、僵直性脊椎炎; This is a biotechnological future in the 21th century. And it will be made giant strides in the transcutaneous medication. It is importance progress of the medical iontophoretic technology. Therefore, it may be change to a new world from the traditional Chinese herbs medication by using the way. The first, we tried to do a summary of the basic medical iontophoretic experiment in recent and future developments in our literature. And the secondary, we tried to do a simple meta analysis for the Chinese herbs iontophoresis from 1958 to 2001 year, and collected about 492 study papers, by the treated disease, report year, study office, author, and drugs. They will be show that Chinese herbs iontophoresis of the recently clinic applied conduction. And next, there are introduction that the Chinese traditional minutes, modern pharmacology, and the clinic adaptation of the Radix Tripterygii Wilfordii and the ankylosin spondylosis. At last, we tried to do a clinic tried about the tripterygic iontophoresis with acupuncture to release the back pain of the ankylosin spondylisis and analysis & statistics the results to arrive upon the object of west-east medical communion. So we collected 25 akylosin spondylosis patients who have back pain onset, and was treated for 1 month (4 weeks, 29 days) in one study course. There are 12 patients belong to A group, and the others belong to B group. In the A group, the tripterigic iontophoresis is treated in the first week, distal water iontophoresis is used in 3rd week, only used acupuncture in the 2nd and 4th week . Contrary, it is reversed in B group, that is used distal water iontophoresis in 1st week, tripterigic iontophoresis in 3rd week, and the others treatments are all the same. We check up blood routine and biochemical examination at every Monday, and the pain index & clinic side effect list at every day before treatments. Compared with distal water and tripterygic iontophoresis, and added up together acupuncture, there are clinic results for the back pain of ankylosin spondylosis. There are not only analgesic effect but also anti-inflammation effect in tripterygic state, and the duration can be over 72 hours. In the distal water iontophoresis and only acupuncture state, there are only short terms of analgesia, not any anti-inflammation effect. KEY WORDS : Iontophoresis, TCM Literatures, Acupuncture, Tripterygii, Akylosin spodylosis.
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