中藥指標成分及摻加西藥成分之分析方法研究; Analysis of marker constituents and synthetic therapeutic substances adulterated in traditional Chinese medicines

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題名:	中藥指標成分及摻加西藥成分之分析方法研究;Analysis of marker constituents and synthetic therapeutic substances adulterated in traditional Chinese medicines
作者:	顧祐瑞;KU, YOE-RAY
貢獻者:	中國醫藥學院中國藥學研究所
關鍵詞:	中藥製劑;指標成分;中藥摻加西藥;高效液相層析;毛細管電泳;固相萃取;茶葉;traditional Chinese medicine;marker constituent;adulterant;high-performance liquid chromatography;capillary electrophoresis;solid-phase extraction;tea
日期:	1999
上傳時間:	2009-11-26 11:59:45 (UTC+8)
摘要:	摘要中藥製劑中摻加西藥成分，若在不知情下而長期服用，對身體健康不無影響，另對毒、副作用較強之中藥，造成之危害恐更為顯著。因此行政院衛生署為保護國民之用藥安全，禁止於中藥製劑中摻加西藥成分。至於中藥材本身所含之化學成分很複雜，加上其基原、產地無法充分掌握之情況下，要建立其品質管制標準有其困難，特別是由多味藥材組成之方劑，更加困難。本研究以固相萃取 (SPE) 及高效液相層析 (HPLC) 或毛細管電泳層析(HPCE)，系統性地分析支氣管鬆弛劑 (包括caffeine, theophylline, theobromine, diprophylline及proxyphylline)、類固醇(betamethasone, cortisone acetate, dexamethasone, hydrocortisone acetate, methylprednisolone, prednisolone, prednisone及triamcinolone)、減肥藥 (clobenzorex, diethylpropion, fenfluramine, methamphetamine, phenylpropanolamine及phentermine) 及胃腸藥 (cimetidine, homatropine, metoclopramide, pirenzepine, ranitidine及scopolamine butylbromide) 等四類西藥成分。在中藥製劑方面，則應用SPE及HPLC分析含茶葉方劑 (川芎茶調散、三黃石膏湯、滋腎明目湯、辛夷散、蒼耳散及香芎散) 中之caffeine。本研究建立了上述四類西藥成分摻加於中藥製劑及含茶葉方劑中之caffeine之前處理及分析方法，而這些方法均可用於實際檢體之分析。; ABSTRACT The adulteration by synthetic therapeutic substances in traditional Chinese medicines (TCM) has been reported on many occasions and has been a public health concern in Taiwan over the past years. The term "adulteration" refers to TCM tested and found to contain chemical substances not prescribed or labeled as part of the intended use. The adulteration by synthetic therapeutic substances in TCM was banned for the reasons of public safety by the health authorities in Taiwan. Four pharmacological categories of chemical drugs, xanthine bronchodilators: caffeine, diprophylline, proxyphylline, theobromine and theophylline; steroids: betamethasone, cortisone acetate, dexamethasone, hydrocortisone acetate, methylprednisolone, prednisolone, prednisone and triamcinolone; anorexics: clobenzorex, diethylpropion, fenfluramine, methamphetamine, phenylpropanolamine and phentermine and gastrointestinal drugs: cimetidine, homatropine, metoclopramide, pirenzepine, ranitidine and scopolamine butylbromide, adulterated in TCM were assayed by solid-phase extraction with high-performance liquid chromatography or high-performance capillary electrophoresis. A high-performance liquid chromatographic method in combination with C18 reversed phase SPE was also developed for the determination of caffeine in traditional Chinese medicinal prescriptions which contain Theae Folium. Six frequently used prescriptions were studied by above methods. These prescriptions include Shin-Yi-San, Chuan-Chyong-Char-Tyau-San, Tsang-Eel-San, San-Hwang-Shyr-Gau-Tang, Tzy-Shenn-Ming-Mu-Tang and Shiang-Chyong-San.
顯示於類別:	[中國藥學研究所(已停用)] 博碩士論文

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