藥用及保健植物---台灣金線蓮粗萃取物的毒理學及藥理學研究

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 醫學系 > 研究計畫 > Item 310903500/23839

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题名:	藥用及保健植物---台灣金線蓮粗萃取物的毒理學及藥理學研究 Toxicological and Pharmacological Studies of Crude Extracts of Anoectechilus formosanus
作者:	林文川;許朝添;鍾景光;張惠玲;彭文煌
贡献者:	中國醫藥大學藥理科
关键词:	台灣金線蓮;萃取物;毒理學;藥理學;Anoectochilus formosanus;Extract;Toxicology;Pharmacology
日期:	1999
上传时间:	2009-11-09 11:34:11 (UTC+8)
摘要:	本實驗評估臺灣金線連水粗萃取物 (AFE) 連續經口投與90天對大鼠的毒性作用。AFE使用的劑量為每天投與0.5 g/kg 或2.0 g/kg。雄性大鼠2.0 g/kg組體重減輕。血液學檢查:雌性大鼠2.0 g/kg組出現中性球減少情形。血清生化學檢查:雌性大鼠2.0 g/kg組的乳酸去氫酵素活性及鈣、磷濃度下降。尿液分析:雄性大鼠2.0 g/kg組出現輕微酮尿。臟器重量:雌性大鼠2.0 g/kg組的腦下垂體、腎臟、肝臟增重,子宮減重,但並無實質上的病理組織變化。大鼠長期投與AFE,安全劑量在0.5 g/kg以下。本實驗也進行對於妊娠期和授乳期的母鼠連續投與AFE觀察其對新生兒的影響。母鼠從妊娠第7天至產後第28 天,每天投與AEF 0.5 g/kg、2.0 g/kg。得到下列結果:(1) AFE對母鼠的體重、攝食量沒有影響。(2) AFE對母鼠的分娩、及新生兒的死產數、活產數、出生指數沒有影響。(3) AFE對產後4 天新生兒的生存指數、及離乳指數沒有影響。(4) AFE對新生兒的體重增加、攝食量沒有影響。(5) AFE對新生兒的自發運動量、學習能力沒有影響。(6) 目測觀察外型AFE沒有致畸胎作用。以上結果顯示AFE在2.0 g/kg/day的劑量對母鼠、胎兒、新生兒沒有影響。 The 90-day repeated oral dose toxicity study of a crude aqueous extracts of Anoectochilus formosanus Hayata (AFE) was evaluated in rats. AFE was conducted at once-daily doses of 0, 0.5 and 2.0, g/kg. Inhibition of body weight gain was noted in the male group at 2.0 g/kg. In hematology, decreased amount of segmented neutrophil was observed in females of the 2.0 g/kg dose groups. In blood chemistry, a decrease in lactate dehydrogenase activity was observed in females of the 2.0 g/kg dose group. In addition, females given 2.0 g/kg showed a slight decrease in calcium and phosphorus levels. Urinalysis showed a slight increase in ketones in males of the 2.0 g/kg dose group. Increases in weight of pituitary, liver and kidney in the females of 2.0 g/kg dose group were observed, with no histopathological changes. In conclusion, the toxicological no-observed levels in rats were thought to be 0.5 g/kg or below. AFE was administered orally to female rats at daily dose levels of 0, 0.5 and 2.0 g/kg from day 7 of gestation to postpartum day 28. Results obtained were as follows: 1) AFE did not affect the body weight gains, food intake in F0 dams. 2) Delivery status in F0 dams as well as number of stillborn pups, number of live pups and birth index were not affected by AFE. 3) AFE did not affect the viability index on postnatal day 4 and weaning index in F1 rats. 4) Body weight gain and food consumption were not affected in F1 rats given AAF. 5) AFE did not alter learning, spontaneous motor activity in both male and female F1 rats. 6) Teratogenicity of AFE could not be detected. The result indicate that no-effect dose level of AFE is 2.0 g/kg/day for dams, fetuses and offspring.
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