Effects of glucose, fructose and 5-hydroxymethyl-2-furaldehyde on the presystemic metabolism and disposition of glycyrrhizin in rabbits.

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 藥學院 > 藥學系暨碩博士班 > 會議論文 > Item 310903500/23057

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题名:	Effects of glucose, fructose and 5-hydroxymethyl-2-furaldehyde on the presystemic metabolism and disposition of glycyrrhizin in rabbits.
作者:	(M.J. Wang);李珮端(Pei-Dawn Lee Chao);侯鈺琪(Hou YuChi);徐素蘭;溫國慶(Kuo-Ching Wen)
贡献者:	藥學院藥學系
日期:	2004-05-30
上传时间:	2009-09-07 15:21:34 (UTC+8)
摘要:	Purpose: Licorice and honey-treated licorice are widely used in clinical Chinese medicine. Our previous study indicated that honey significantly altered the presystemic metabolism and pharmacokinetics of glycyrrhizin (GZ) in rabbits. This study aimed to investigate the causative component in honey. Methods: Rabbits were given GZ with and without glucose, fructose or 5-hydroxymethyl-furaldehyde (HMF), respectively, in crossover designs. HPLC method was used for the determination of concentrations of GZ and glycyrrhetic acid (GA) in serum as well as GA and 3-dehydroGA in feces suspension. Noncompartment model was used for the calculation of pharmacokinetic parameters and ANOVA was used for statistical comparison. Results: The pharmacokinetics of GZ and GA were not significantly altered when glucose or fructose was coadministered, whereas the AUC of GA was significantly increased by 29 % when HMF was coadministered. In vitro study using feces to incubate GZ or GA indicated that the oxidation of GA to 3-dehydroGA was significantly inhibited in the presence of HMF and it might result in more GA available for absorption. Conclusions: HMF was the causative component in honey that affected the presystemic metabolism and pharmacokinetics of GZ and might increase the toxicity of GZ.
關聯:	2nd World congress of the board of Pharmaceutical sciences of FIP
显示于类别:	[藥學系暨碩博士班] 會議論文

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