Synthesis of (2E)-3-{2-[(Susbstituted benzyl)oxy]-susbstituted phenyl}acrylaldehydes as Novel Anti-inflammatory Agents

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Title:	Synthesis of (2E)-3-{2-[(Susbstituted benzyl)oxy]-susbstituted phenyl}acrylaldehydes as Novel Anti-inflammatory Agents
Authors:	郭盛助(Sheng-Chu Kuo);賴玉琪(Yu-Chi Lai);(Shu-Wei Hsu);王繼平;黃麗嬌(Li-Jiau Huang)
Contributors:	藥學院藥物化學研究所
Date:	2003-12-07
Issue Date:	2009-09-07 12:24:17 (UTC+8)
Abstract:	In the previous paper, several benzyloxybenzaldehyde isomers were synthesized and found to have significant inhibitory activity toward neutrophil superoxide formation. Among them, 2-benzyloxybenzaldehyde (CCY1a) was the most promising one, which was identified as an novel adenyl cyclase inhibitor. In this present work, CCY1a was selected as lead compound, a series of CCY1a derivatives was synthesized and their inhibitory effects on neutrophil superoxide anion formation was evaluated. The structure-activity relationships in this series were also examined. All of the derivatives of (2E)-3-{2-[(substituted benzyl)oxy]-substituted phenyl}acrylaldehyde showed potent activity. Among them, (2E)-3-[2-(benzyloxy)-5-methoxyphenyl]acrylaldehyde was the most promising one which could provide a novel structural prototype for anti-inflammatory agents.
Relation:	九十二年度中國藥學會年會暨學術研討會
Appears in Collections:	[Graduate Institute of Pharmaceutical Chemistry] Proceedings

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