Synthesis and cytotoxicity of the 4-(1-benzyl-1H-indazol-3-yl)-N-hydroxybenzamide analogs?

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Title:	Synthesis and cytotoxicity of the 4-(1-benzyl-1H-indazol-3-yl)-N-hydroxybenzamide analogs?
Authors:	(Hua-Sin Chen(陳華);(Chiung-Wen Kuo);黃敬哲(Jing-Je Huang);(You-Sin Chang);(Chun-Ta Feng);郭盛助(Sheng-Chu Kuo);黃麗嬌(Li-Jiau Huang)?
Contributors:	藥學院藥物化學研究所;?
Date:	2005-09-4?
Issue Date:	2009-09-07 12:18:27 (UTC+8)
Abstract:	Ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) was first synthesized in our laboratory as a novel anti-angiogenic agent. Recently, a series of YD-3 derivatives were synthesized, and these compounds were assayed for their cytotoxicity against HL-60 human leukemia cells. Among them, compound 4-(1-benzyl-1H-indazol-3-yl)-N-hydroxybenzamide (I) (IC50 = 2.5 mM) exhibited significant cytotoxicity against HL-60 human leukemia cells, which was superior to YD-3 (IC50 = 50.0 mM). Encouraged by this initial result, compound I was used as a lead compound, and a series of its analogs were synthesized and evaluated for their cytotoxicity of human hepatoma cell line (Hep 3B), human lung carcinoma cell line (A549), human colorectal adenocarcinoma cell line (COLO 205), human cervix adenocarcinoma cell line (HeLa), and human leukemia cell line (HL-60).?
Relation:	2005藥物化學研討會?
Appears in Collections:	[Graduate Institute of Pharmaceutical Chemistry] Proceedings

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