Investigation of antitumor mechanism of 1-(3, 4- substituted phenyl)-3,5-tetradecenedione derivatives in human leukemia cell lines

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 藥學院 > 藥物化學研究所 > 會議論文 > Item 310903500/22727

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题名:	Investigation of antitumor mechanism of 1-(3, 4- substituted phenyl)-3,5-tetradecenedione derivatives in human leukemia cell lines
作者:	徐美華(Mei-Hua Hsu);郭盛助(Sheng-Chu Kuo);(Chun-Jen Chen);賴雅韻(Ya-Yun Lai);(Jing-Gung Chung);黃麗嬌(Li-Jiau Huang)
贡献者:	藥學院藥物化學研究所
日期:	2004-05-29
上传时间:	2009-09-07 12:17:29 (UTC+8)
摘要:	Purpose: It has been shown that some of ginger derivatives possess antitumor activity (such as [6]-gingerol and [6]-paradol), but the antitumor activity of other skeletal derivatives have not yet been determined. We have synthesized new gingerdione derivatives and found that they could inhibit human leukemia cells growth. The purpose of this study is to determine the action mechanism of gingerdione derivatives on human leukemia cells. Methods: Human leukemia cells were treated with newly synthesized gingerdione derivatives or vehicles. Cellular proliferation rate was determined by MTT assay. Antitumor mechanisms were determined by using cell cycle analysis, DNA fragmentation, and RT-PCR technology. Results: Among the newly synthesized compounds, we found that 1-(3, 4-dimethoxyphenyl)-3, 5-tetradecenedione (I8) is most effective against HL-60 cells with IC50 values of approximately 22.4μM. Furthermore, I8 may exert its antitumor action by inducing cell cycle arrest at G0/G1 phase and promoting cell apoptosis. Conclusions: Among the newly synthesized compounds, we found that I8 is most effective against leukemia cells. Therefore, I8 may have potential to be developed as a novel antitumor agent.
關聯:	Pharmaceutical Sciences World Congress (PSWC2004)
显示于类别:	[藥物化學研究所] 會議論文

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