Synthesis and Mechanism Study of 2-Aryl-2H-[1,2,4]triazoloquinolin-3-one and 2-Aryl-2H-[1,2,4]triazoloisoquinolin-3-one Derivatives

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Title:	Synthesis and Mechanism Study of 2-Aryl-2H-[1,2,4]triazoloquinolin-3-one and 2-Aryl-2H-[1,2,4]triazoloisoquinolin-3-one Derivatives
Authors:	翁豐富(Fung Fuh Wong)
Contributors:	藥學院藥物化學研究所
Date:	2006-11-24
Issue Date:	2009-09-07 12:16:18 (UTC+8)
Abstract:	Two isomers of 2-aryl-2H-[1,2,4]triazoloquinolin-3-one and 2-aryl-2H-[1,2,4]triazoloisoquinolin-3-one derivatives were synthesized by using α-chloroformylarylhydrazines hydrochloride with quinoline. The isomers were isolated and fully characterized by spectroscopic. Following the furthure X-ray crystallographic analysis, we supposed a plausible mechanism through N-substitution, ring opening, cyclization and dehydrogenation to provide the 2-aryl-2H-[1,2,4]triazoloisoquinolin-3-ones.
Relation:	中國化學學會九十五年年會
Appears in Collections:	[Graduate Institute of Pharmaceutical Chemistry] Proceedings

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