Marked decrease of cyclosporin absorption caused by phellamurin in rats.

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 藥學院 > 藥學系暨碩博士班 > 期刊論文 > Item 310903500/2267

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题名:	Marked decrease of cyclosporin absorption caused by phellamurin in rats.
作者:	陳鴻儀;(T.S. Wu);(S.F. Su);郭盛助(Sheng-Chu Kuo);李珮端(Pei-Dawn Lee Chao)*
贡献者:	藥學院藥學系
关键词:	Phellamurin;cyclosporin;pharmacokinetic interaction;Phellodendron wilsonii;Rutaceae;flavonoid
日期:	2002
上传时间:	2009-08-19 17:29:02 (UTC+8)
摘要:	Phellamurin is a flavonoid glycoside that is abundant in the leaves of Phellodendron wilsonii Hayata et Kanehira (Rutaceae). In vitro everted rat intestine study indicated that phellamurin inhibited intestinal P-glycoprotein in a dose-dependent manner. In order to investigate the effect of phellamurin on cyclosporin absorption and disposition, rats were given cyclosporin (5 mg/kg) with or without phellamurin in a parallel design. Fluorescence polarization immunoassay was used to determine the blood concentration of cyclosporin. Unanticipatedly, our results indicated that the coadministration of phellamurin significantly decreased the Cmax of cyclosporin by 77 % and reduced the AUC0-∞ of cyclosporin by 56 %. This indicated that a serious interaction occurred between phellamurin with cyclosporin. To ensure the efficacy of cyclosporin, we suggest that the coadministration of phellamurin or Phellodendron wilsonii with cyclosporin should be avoided.
關聯:	PLANTA MEDICA 68(2):138~141
显示于类别:	[藥學系暨碩博士班] 期刊論文

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