Synthesis of 1-Substituted 2-(5-methyl-2-furyl)-5-phenylpyazoles as Antiplatelet Activity Agents?

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Title:	Synthesis of 1-Substituted 2-(5-methyl-2-furyl)-5-phenylpyazoles as Antiplatelet Activity Agents?
Authors:	連金城(Lien,Jin-Cherng);侯曼貞(Hour,Mann-Jen);黃麗嬌(Huang,Li-Jiau);(吳俊昇);(陳柏舟);(鄧哲明);郭盛助(Kuo,Sheng-Chu)?
Contributors:	藥學院藥物化學研究所?
Date:	2005-09-4?
Issue Date:	2009-09-07 12:11:20 (UTC+8)
Abstract:	Our research suggests that 1-benzyl-3-(5’-hydroxymethyl-2’-furyl)indazole (YC-1) activates sGC of human platelet by the NO-independent mechanism, and exerts its antiplatelet effect through the sGC/cGMP pathway. To further explore the structure-activity relationships of YC-1 analogs, 1-benzyl-3-(5-methyl-2-furyl)indazole was synthesized and demonstrated antiplatelet activity comparable to that of YC-1. Encourage by this result, we are intending to synthesize its pyrazole analogs -- 1-(substituted benzyl)-3-(5-methyl-2-furyl)-5-phenylpyrazoles. The antiplatelet activities of the target compounds were examined. Some of them exhibit significantly inhibitory effect against collagen- and ADP-induced platelet aggregation.?
Relation:	2005年藥物化學研究討會?
Appears in Collections:	[Graduate Institute of Pharmaceutical Chemistry] Proceedings

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