A new safe and convenient transformation has been developed. In the presence of cesium formate in dry
MeOH solution, a-haloketones underwent direct conversion reaction to afford a-hydroxyketone in excellent
yields. Furthermore, this methodology can be extended and applied in 2-chloro-N-(1,3-diphenyl-1Hpyrazol-
5-yl)acetamide, 2-chloro-N-(2,6-dimethylphen-yl)acetamide, 1-(bromomethylsulfonyl)benzene,
and N-(bromomethyl)phthalimide to give the corresponding products in moderate to excellent yields.
Crown Copyright 2009 Published by Elsevier B.V. All rights reserved.
關聯:
JOURNAL OF ORGANOMETALLIC CHEMISTRY 694(21):3452~3455
