中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/21078
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 29490/55136 (53%)
造访人次 : 1511841      在线人数 : 402
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于CMUR ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/21078


    题名: ROLES OF NITRIC OXIDE IN CRANIAL VASODILATOR MECHANISM IN THE DORSAL FACIAL AREA OF MEDULLA IN CATS
    作者: 龔志力;(Y.T Chiu);(N.N Lin);(C.C Cheng);(J.S Kuo)*
    贡献者: 醫學院醫學系學士班生理學科
    日期: 2006-03-18
    上传时间: 2009-09-07 10:42:49 (UTC+8)
    摘要: Glutamate stimulation of the dorsal facial area (DFA), an area located just dorsal to the facial area, produces increase in the blood flow of ipsilateral common carotid artery (CCA). Nitric oxide (NO) acts as a neurotransmitter and is closely related with glutamate in central nervous system. Whether NO might interact with glutamate to affect CCA blood flow was not known. Perfusion in the DFA of S-nitroso-N-acetylpenicillamine, a NO donor, increased glutamate concentration in the DFA and elicited CCA blood flow increase. Microinjection of sodium nitroprusside (NO donor) in the DFA caused dose-dependent increase in CCA blood flow. Microinjections of L-arginine (NO precursor) in the DFA also caused dose-dependent increase in CCA blood flow, suggesting NO synthesis in the DFA. Microinjection in the DFA of NG-nitro-arginine methyl ester (L-NAME, a NOS inhibitor) or methylene blue (guanylate cyclase inhibitor) caused a decrease in CCA blood flow, suggesting a tonic release of NO. Cells (probably neurons) containing NO synthase (NOS) were found in the DFA as approached by histochemical staining of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d), a maker of NOS. In conclusion, NOS-containg cells or neurons are present in the DFA, and appear to release NO in tonic fashion and to interact with glutamate for increasing CCA blood flow. The result may provide some help in developing therapeutic strategy for CCA vascular disorders.
    關聯: 第二十一屆生物醫學聯合學術年會
    显示于类别:[醫學系] 會議論文

    文件中的档案:

    没有与此文件相关的档案.



    在CMUR中所有的数据项都受到原著作权保护.

    TAIR相关文章

     

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈