中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/2104
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    题名: The ameliorating effects of LiuWei Dihuang Wang on cycloheximide-induced impairment of passive avoidance performance in rats
    作者: 吳啟瑞(Chi-Rei Wu)*;(Li-Wei Lin);(Wen-Hsin Wang);謝明村
    贡献者: 藥學院中國藥學研究所
    关键词: LiuWei Dihuang Wang;Passive avoidance task;Cycloheximide;Memory
    日期: 2007-08
    上传时间: 2009-08-19 17:24:46 (UTC+8)
    摘要: The ameliorating effects of aqueous and ethanolic extracts of LiuWei Dihuang Wang (LDWW and LDWE) after single, 1-week or 2-week consecutive treatment on the cycloheximide-induced amnesia by using the passive avoidance task in rats were studied. After single treatment, LDWW and LDWE (1 and 2 g/kg) significantly prolonged the shortened step-through latency induced by CXM and their potency was equal. LDWW at 1 g/kg after 1-week consecutive treatment or at 0.1 g/kg after 2-week consecutive treatment almost completely reversed CXM-induced amnesia. LDWW at any dose alone after single, 1-week or 2-week consecutive treatment did not influence the step-through latency in the training trial in rats. Furthermore, muscarinic antagonist scopolamine, peripheral cholinergic antagonist scopolamine methylbromide, serotonin precursor 5-hydroxytryptamine and serotonin releaser p-chloroamphetamine could block the ameliorating effects of LDWW. GABAA receptor antagonist bicuculline and GABAB receptor agonist baclofen also blocked the ameliorating effects of LDWW. These results suggest that the ameliorating effects of LDW whose potency were parallel to treatment duration might be related to activating peripheral cholinergic neuronal system and modulating the central nervous system.
    關聯: JOURNAL OF ETHNOPHARMACOLOGY113(1):79~84
    显示于类别:[中國藥學研究所(已停用)] 期刊論文

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