中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/21023
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    題名: THE EFFECTS OF CCY1a-E2 ON WEHI-3 LEUKEMIA MICE IN VIVO
    作者: 楊家欣;李妙蓉;張瓊云(Chiung-Yun Chang);楊雅茹(Y.J. Yang);王釧如(C.R. Wang);郭盛助;林錦芬*
    貢獻者: 醫學院醫學系學士班生化學科
    日期: 2004-04-10
    上傳時間: 2009-09-07 10:40:38 (UTC+8)
    摘要: Previously we demonstrated that CCY1a-E2 was the most potent derivative of benzyloxybenzaldehyde and it inhibited growth of leukemia cells by induction of cell cycle arrest and apoptosis. In this study, our data showed that CCY1a-E2 also inhibited the proliferation of WEHI-3 leukemia cells in a dose-dependent manner, and the IC50 for 24-hour treatment was 5.0 mM approximately. The purpose of this study was to evaluate the anti-cancer activity of CCY1a-E2 in syngeneic BALB/c mice bearing murine WEHI-3 cells. To confirm the induction of leukemia animal model, BALB/c mice were administrated intravenously at doses of 5x106, 1x106, and 2x105 WEHI-3 cells, respectively. Leukemia were successfully induced 14-28 days later at the dose of 5x106 and 1x106 cells. To assess the acute and chronic toxicity of CCY1a-E2, BALB/c mice were administrated intravenously with 100mg/kg of CCY1a-E2 for 7 days continuously and then sacrificed at the 7th day or the 28th day. No significant toxicity was observed in the CCY1a-E2 treated mice. To evaluate the anti-cancer activity, BALB/c mice were administrated CCY1a-E2 intravenously (100mg/kg) with 1x106 WEHI-3 cells simultaneously, or 7 days after WEHI-3 cells injection. CCY1a-E2 significantly enhanced survival rate, improved the body weight loss, reduced the enlargement of spleen and lymph nodes, and prevented liver metastases in the WEHI-3 bearing mice. Furthermore, analysis of peripheral blood revealed that the number of leukocytes in the CCY1a-E2 treated leukemia mice were significantly lower than that in leukemia mice without treatment. Taken together, CCY1a-E2 has potentially anticancer activity.?
    關聯: The 19th Joint Annual Conference of Biomedical Sciences (2004)
    顯示於類別:[醫學系] 會議論文

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