Apolipoprotein E (ApoE) and peroxisome proliferator-activated receptor a (PPARa) play an important role in lipid metabolism. Preliminary evidence suggests that ApoE genotype appears to be a risk factor for breast cancer. Moreover, we found PPARa protein was more expressed in breast cancer tissue than that in the surrounding cancer-free tissue. We screened the PPARa and ApoE genotypes in 299 breast cancer patients and 232 non-cancer controls and determined the synergistic effect of the ApoE and PPARa polymorphisms on the risk for breast cancer. We found risk for breast cancer was associated with the synergistic effect of ApoE and PPARa polymorphisms. Carries of a PPARa-F24 allele and an ApoE e4 allele showed higher risk for breast cancer than carries of a PPARa-F24 allele and an ApoE e3 allele (p = 0.046, OR = 1.721, 95% CI: 1.009-2.937). In addition, HER-2/neu negative status correlated with carries of an ApoE e4 allele and a PPARa-F24 allele (p = 0.006). Carries of a PPARa-F24 allele and an ApoE e4 allele presented with a decreased risk for ductal carcinoma in situ (p = 0.021). Patients with a PPARa-F24 allele and an ApoE e2 allele showed higher lymphatic invasion (p = 0.027) than with a PPARa-F24 allele and an ApoE e3 allele. These results suggest that the synergistic effect of ApoE and PPARa-F24 allele may increase the risk for breast cancer.?
關聯:
The 20th Joint Annual Conference of Biomedical Sciences (2005)
