Molecular Structure Modeling of Membrane Protein GABAA Receptor and Zolpidem Docking Study

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Title:	Molecular Structure Modeling of Membrane Protein GABAA Receptor and Zolpidem Docking Study
Authors:	(Lin, Jing-li);陳語謙
Contributors:	生命科學院生物科技學系
Date:	2006-04-28
Issue Date:	2009-09-07 09:26:48 (UTC+8)
Abstract:	Membrane protein gamma-aminobutyric acid type A receptor (GABAA receptor) was built in silico by the process of comparative modeling. Each subunit of GABAA receptor was built one by one in accordance with the template subunits. This building strategy indicated a consequence that every built structure was carrying proper 3-dimentional coordinates. These coordinates helped to combine all the subunits well. The benzodiazepine(BZ) binding site was located in a binding pocket between 2 subunits of GABAA receptor. Zolpidem, Benzodiazepine derivative, was selected to dock into the binding site. The binding pocket was much larger than zolpidem. Therefore, the pocket was divided into partitions for searching the suitable place for zolpidem to dock in.
Relation:	第二屆生物資訊研討會
Appears in Collections:	[Department of Biological Science and Technology] Proceedings

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