Shikonin inhibits the growth and N-acetylation of 2-aminofluorene in Helicobacter pylori from ulcer patients.

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 醫學系 > 期刊論文 > Item 310903500/1966

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题名:	Shikonin inhibits the growth and N-acetylation of 2-aminofluorene in Helicobacter pylori from ulcer patients.
作者:	郭秀滿;夏德椿(Te-Chun Hsia);(YC Chuang);(HF Lu);(SY Lin);鍾景光(Jing-gung Chung)*
贡献者:	醫學院醫學系學士班寄生蟲學科
日期:	2004-05
上传时间:	2009-08-19 17:23:21 (UTC+8)
摘要:	N-acetyltransferase (NAT) plays an important role in the N-acetylation of arylamine carcinogens and drugs. Shikonin has been shown to induce apoptosis and inhibit angiogenesis in vivo and in vitro. In this study, shikonin elicited dose-dependent bacteriostatic activity in Helicobacter pylori cultures. Arylamine N-acetyltransferase (NAT) activity (N-acetylation of 2-aminofluorene) was determined in the Helicobacter pylori isolated from peptic ulcer patients. Bacterial cytosols or intact cells with or without specific concentrations of shikonin co-treatment showed different percentages of 2-aminofluorene acetylation. Shikonin also inhibited N-acetylation of 2-aminofluorene in these examined Helicobacter pylori cytosols and intact cells in a dose-dependent manner. The apparent values of Km and Vmax were decreased after co-treatement with 4 μM shikonin in the cytosol of Helicobacter pylori.
關聯:	ANTICANCER RESEARCH 24(3A):1587~1592
显示于类别:	[醫學系] 期刊論文

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