Inhibitory actions of serotonin on glutamate release in dorsal medulla suppressing systemic arterial pressure of cats

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 醫學系 > 期刊論文 > Item 310903500/1936

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题名:	Inhibitory actions of serotonin on glutamate release in dorsal medulla suppressing systemic arterial pressure of cats
作者:	龔志力;(Yung-Tsung Chiu);(Nai-Nu Lin);林欣榮(Shinn-Zong Lin);(Fu-Chou Cheng);(Jon-Son Kuo)*
贡献者:	醫學院醫學系學士班生理學科
关键词:	Brain stem;Microdialysis;Neurotransmitter;Excitatory amino acids;Pressor area;Sympathetic center
日期:	2004-01
上传时间:	2009-08-19 17:23:10 (UTC+8)
摘要:	The role of serotonin and glutamate release in dorsal medulla (DM) for regulation of systemic arterial pressure (SAP) was examined with microdialysis and high performance liquid chromatograph in anesthetized cats. KCl-perfusion in DM increased serotonin and glutamate concentrations in DM. Perfusion of serotonin resulted in decreases in glutamate concentration and SAP. Perfusion of alaproclate, a serotonin reuptake inhibitor that produced an increase in serotonin concentration in DM, had the same results as perfusion of serotonin. In conclusion, serotonin and glutamate appeared to be tonically and endogenously released from nerve terminals in DM, and the decrease in SAP could be attributed to the decreased glutamate release resulting from inhibitory action of serotonin in DM. The putative roles of serotonin and glutamate in DM may be important in SAP regulation.
關聯:	NEUROSCIENCE LETTERS 355(1-2):73~76
显示于类别:	[醫學系] 期刊論文

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