Association Analysis of Polymorphisms in the Interleukin-1β-511 Promoter and Interleukin-1 Receptor Antagonist Gene with Pediatric Asthma from Taiwan.

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Title:	Association Analysis of Polymorphisms in the Interleukin-1β-511 Promoter and Interleukin-1 Receptor Antagonist Gene with Pediatric Asthma from Taiwan.
Authors:	謝佳璋;蔡輔仁(Tsai,Fuu-Jen);(Chow WC);吳啟瑞(Wu,Chi-Rei);(Kobayashi H)
Contributors:	醫學院醫學系學士班小兒學科
Date:	2004-01
Issue Date:	2009-08-19 17:22:53 (UTC+8)
Abstract:	Asthma is a chronic inflammatory disease of the airway. Both genetic and environmental factors are thought to be involved in the onset of the disease. We aimed to investigate if the interleukin-1β (IL-1β)-511 promoter and IL-1 receptor antagonist (IL-1Ra) gene polymorphisms could be used as markers of susceptibility to bronchial asthma in children. Children were divided into two groups: (1) bronchial asthma (n = 202) and (2) healthy control (n = 144). Polymorphisms for the IL-1β-511 promoter and IL-1Ra were detected by polymerase chain reaction. Genotypes and allelic frequencies for these polymorphisms in both groups were compared. The difference in the proportions of different IL-1β-511 promoter and IL-1Ra polymorphisms in both groups were not significant. Proportions of C homozygote/heterozygote/T homozygote for IL-1β-511 promoter were (1) 34.2/46.0/19.8% in the asthma group and (2) 33.3/48.6/18.1% in the control group. Alleles I/II/III/IV for IL-1Ra were (1) 91.8/7.7/0.5/0% in the asthma group and (2) 90.3/9.4/0/0.3% in the control group. There was no association of pediatric asthma with the IL-1β-511 promoter and IL-1Ra gene polymorphisms. These polymorphisms are not useful markers for prediction of asthma susceptibility.
Relation:	Pediatric Asthma, Allergy & Immunology 17(1):53~57
Appears in Collections:	[School of Medicine] Journal articles

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