Apolipoprotein E4 allele influences the response of plasma triglyceride levels to tamoxifen in breast cancer patients

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 分子系統生物醫學研究所 > 期刊論文 > Item 310903500/1840

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题名:	Apolipoprotein E4 allele influences the response of plasma triglyceride levels to tamoxifen in breast cancer patients
作者:	張乃文(Nai-Wen Chang);陳緋娜(Fei-Na Chen);(Chen-Teng Wu);林錦芬(Lin, Chin-Fen);(Dar-Ren Chen)
贡献者:	醫學院分子系統生物醫學研究所
关键词:	Apolipoprotein E4 allele;Tamoxifen;Breast cancer;Hypertriglyceridemia Article Outline
日期:	2009-03
上传时间:	2009-08-19 17:09:33 (UTC+8)
摘要:	Background Apolipoprotein E4 (APOE4) allele is an important risk factor for breast cancer and affects clearance of chylomicron remnants. Tamoxifen therapy increases serum triglyceride levels and sometimes inducing severe hypertriglyceridemia in breast cancer patients. Methods Thirty-three women with breast cancer were recruited to examine the APOE polymorphism and fasting plasma lipid profiles before and after tamoxifen treatment for 6 months. Results We found that plasma lipid profiles changed in accordance with the APOE4 allele after tamoxifen treatment for 6 months. Especially plasma triglyceride levels significantly decreased in the APOE4-positive patients (p = 0.025), while there was no change in APOE4-negative patients (p = 0.189). The total plasma cholesterol levels were reduced in APOE-4 positive patients after 6-month tamoxifen treatment (p = 0.014). The levels of plasma low density lipoprotein cholesterol and high density lipoprotein cholesterol significantly decreased in both APOE4-negative and APOE4-positive patients. Conclusions These findings indicate that the effects of tamoxifen on plasma triglyceride levels are modified by APOE polymorphism. Breast cancer patients with APOE4 allele have low plasma triglyceride levels when receiving tamoxifen therapy. Therefore, we suggest that APOE gene polymorphism is a critical validation before tamoxifen treatment in breast cancer patients.
關聯:	CLINICA CHIMICA ACTA401(1-2):144~147
显示于类别:	[分子系統生物醫學研究所] 期刊論文

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