THE NOVEL INHIBITORS FOR C-MET AND HER2/NEU

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 生命科學院 > 生物科技學系暨碩士班 > 會議論文 > Item 310903500/17663

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题名:	THE NOVEL INHIBITORS FOR C-MET AND HER2/NEU
作者:	(Y.C. Chao1);(C.L. Chen1);(K.T. Chen1);(J.L. Lin1);(Y.C. Tseng2);(S.H. Chuang3);陳語謙(Chen, Yu-Chian)
贡献者:	生命科學院生物科技學系
日期:	2007-03-18
上传时间:	2009-09-04 10:13:31 (UTC+8)
摘要:	C-Met and Her2/neu are members of the tyrosine kinase protein family. They have a relation in many kinds of cancer. We took the templates of C-Met and Her2/neu from Protein Data Bank, and modeled the protein structures. Then, we used the software(Accerlrys) to find the ATP-binding sites to dock with several compounds. To inhibit proliferation on cells, we used the property of the compounds inhibit with ATP combine with the site to terminate phosphorylation of tyrosine kinase. After the calculation from computer, we got the interaction energy, the results show that D50300401Z01, D50300601Z01, D50306701Z01, D50307201Z01, D50308501Z01 could have lower interaction energy on C-Met and Her2/neu. And we presumed such compounds may be use for the anti-tumor agents.
關聯:	2007 生醫年會
显示于类别:	[生物科技學系暨碩士班] 會議論文

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