AIMS: The aim of this study is to assess the important factors that influence the postpartum women's quality of life. METHODS: A total of 407 postpartum women between 15 to 44 years old responded to the 28-item Taiwanese version of WHOQOL-BREF questionnaire and other items such as postpartum women's age, education level, employment status, self-evaluated health, preference for boys, method of delivery (natural, assisted with suction cup or C-section), child's gender, weeks since birth and firstborn/non-firstborn. The range of days since birth is from 2 to 113 days. Multiple regression analysis with backward selection technique was used to determine the factors that influenced health-related quality of life (HRQOL). RESULTS: The results showed postpartum women's employment status (p=0.03), self-evaluated health (p