Study of the sampling and analyzing method of the 4,4-Methylene bis(2-chloro

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Title:	Study of the sampling and analyzing method of the 4,4-Methylene bis(2-chloro
Authors:	郭錦堂(Ching-tang Kuo);許惠悰(Hui-Tsung Hsu);(汪禧年)
Contributors:	公共衛生學院環境醫學研究所
Date:	2005-04-20
Issue Date:	2009-09-04
Abstract:	Background. A worker was diagnosed to have bladder cancer in Taiwan (2002). With a suspicion of exposure to 4,4’-Methylene bis(2-chloroaniline) (MOCA) at work as the cause of the disease, we are anxious to establish a sampling and analytical method to measure the chemical with adequate reliability and accuracy. Methods. We used glass fiber filters to collect MOCA particles followed by extraction with methanol and measurement with HPLC-UV detector. Results. We obtained an excellent calibration result with a relative linear correlation greater than 0.999, a detect limit of 16.74 ng, and an average correlation variation of 0.46% in reproducibility. The recovery rates obtained for three different levels of permissible exposure limit(PEL) ranged from 100.1 to 100.6% with the coefficients in variations of concentrations(CV%) and analyses(CVa%) to be 1.22 and 1.0%, respectively. Samples stored with glass fiber filters would sustain for 28 days with a coefficient of variation for quality control samples lower than 3.75%. The relative percent difference for the short-term duplication analyses was lower than 0.5%. This method can get good outcome at work place. Conclusion. Glass fiber filter is an adequate tool to collect MOCA samples with good outcome.Key words：4,4’-Methylene bis(2-chloroaniline),MOCA, bladder cancer, glass fiber, HPLC-UV.
Relation:	第78屆日本產業衛生學會總會
Appears in Collections:	[Graduate Institute of Environmental Medicine] Proceedings

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