Reduction of oxidative stress and apoptosis in hyperlipidemic rabbits by ellagic acid

CMUR > College of Health Care > Graduate Institute of Nutrition > Journal articles > Item 310903500/1672

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/1672

Title:	Reduction of oxidative stress and apoptosis in hyperlipidemic rabbits by ellagic acid
Authors:	余雅美*;張文正(Chang WC);吳介信(Chieh-Hsi Wu);江素瑛(Su-yin Chiang)
Contributors:	健康照護學院營養學系
Keywords:	Antioxidant;Ellagic acid;Oxidative stress;8-(OH)dG;Apoptosis;Atherosclerosis
Date:	2005-11
Issue Date:	2009-08-19 17:05:55 (UTC+8)
Abstract:	Oxidative stress is one of the major risk factors for coronary artery disease. Ellagic acid is a phenolic compound present in fruits and nuts, and has been found to have antioxidative property. Twenty-four New Zealand white (NZW) rabbits were assigned randomly into four dietary groups. The normal group was fed regular rabbit chow, and the cholesterol group was fed a high fat and cholesterol diet. The ellagic acid (E) group and probucol group were fed the same diet as the cholesterol group plus the addition of 1% (w/w diet) ellagic acid and probucol, respectively. Oxidative stress [as measured by plasma lipids, oxygen free radicals and thiobarbituric acid reactive substances (TBARS)] increased in the cholesterol group compared with the normal group; however, it decreased in the probucol and E groups compared with the cholesterol group. Forty-five percent of the intimal surface of the thoracic aorta was covered with atherosclerotic lesions in the cholesterol group, but only 2–3% was covered in the E and probucol groups. The aortic level of 8-(OH)dG and the expression of caspase-8, caspase-9 and Fas ligand were also suppressed after ellagic acid supplement. These results indicated that ellagic acid could prevent atherosclerosis via suppression of oxidative stress and apoptosis in hyperlipidemic rabbits.
Relation:	JOURNAL OF NUTRITIONAL BIOCHEMISTRY 16(11):675~681
Appears in Collections:	[Graduate Institute of Nutrition ] Journal articles

Files in This Item:

File	Size	Format
	58Kb	Unknown	491	View/Open

Loading...