Previous studies have shown that cigarette smoking contributed to various harmful effects for pregnancy maternity and neonates, and cotinine level may be an important indicator of the metabolic process. On the other hand, CYP2A6 is a metabolic enzyme for nicotine to cotinine. The purpose of this study was to evaluate the correlations among infant’s CYP2A6 genetic variants, cotinine levels and birth outcomes (including height, weight, head circumference etc.) for environmental tobacco smoke (ETS) exposed and non-exposed. We recruited 227 paired samples of pregnancy maternity and newborns from gynecology outpatient department of three hospitals in central Taiwan. The blood specimens, neonatal birth outcomes, and structured questionnaire data were collected. Serum cotinine level was determined and CYP2A6 was genotyped. The 227 participants included 121 (53.3%) ETS-exposed and 106 (46.7%) non-ETS exposed individuals. Maternal occupation (P=0.0009) and education level (P=0.0005) were significant variables between the two groups. There was significant difference between two groups in infant’s head circumference (HC) (non-EST: 34.0±2.15cm vs EST: 33.4±1.65cm, p=0.0167). The cotinine levels between maternal and neonatal showed highly significant correlation (r=0.88, p
關聯:
The 55th Annual Meeting of the American Society of Human Genetics
