Inhibitory effect of magnolia officinalis and lovastatin on aortic oxidative stress and apoptosis in hyperlipidemic rabbits.

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 健康照護學院 > 運動醫學系 > 期刊論文 > Item 310903500/1635

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题名:	Inhibitory effect of magnolia officinalis and lovastatin on aortic oxidative stress and apoptosis in hyperlipidemic rabbits.
作者:	張文正(Chang WC)*;余雅美(Yu YM,);徐媛曼(Hsu YM);吳介信(Wu CH);尹寶倫(Yin PL);江素瑛(Chiang SY);洪瑞松(Hung JS)
贡献者:	健康照護學院運動醫學系
日期:	2006-03
上传时间:	2009-08-19 17:04:51 (UTC+8)
摘要:	Oxidative stress and apoptosis are 2 major characteristics of the progression of atherosclerosis. Both lovastatin and Magnolia officinalis are hypocholesterolemic agents. Therefore, we investigated the effect of M. officinalis extract on the prevention of atherosclerosis in comparison with lovastatin. Twenty hyperlipidemic rabbits were served one of the following diets: a high-fat and cholesterol diet (cholesterol group, 10% corn oil and 0.5% cholesterol), a high fat and cholesterol diet supplemented with M. officinalis extract (300 mg/kg) or lovastatin (6 mg/kg). The plasma lipids, oxidative stress (measured by free radical, malondialdehyde, and oxidative DNA damage), and arterial lesions significantly decreased in the M. officinalis and lovastatin groups when compared with the cholesterol group. Moreover, the expressions of Fas ligand, caspase 8, and caspase 9 in the aortic arches were also markedly lowered after M. officinalis and lovastatin supplements. Therefore, the results indicate that the antiatherogenic effect of M. officinalis is involved with a suppression of oxidative stress and with the down-regulation of apoptosis-related gene expression in hyperlipidemic rabbits.
關聯:	JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 47(3):463~468
显示于类别:	[運動醫學系] 期刊論文

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