Effects of short- and long-term hypobaric hypoxia on Bcl2 family in rat heart

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Title:	Effects of short- and long-term hypobaric hypoxia on Bcl2 family in rat heart
Authors:	李信達(Shin-Da Lee);郭薇雯(Wei-Wen Kuo);吳介信(Chieh-Hsi Wu);(Yueh-Min Lin);(James A Lin);(Min-Chi Lu);(Ai-Lun Yang);(Jer-Yuh Liu);(Chung-Jung Liu);黃志揚(Chih-Yang Huang)*
Contributors:	健康照護學院物理治療學系
Date:	2006
Issue Date:	2009-08-19 17:04:02 (UTC+8)
Abstract:	Background Controversial effects of intermittent hypobaric hypoxia such as cardiac damage or cardiac protection are still mysterious. It is unclear if short-term and long-term intermittent hypobaric hypoxic challenges exert different effects on cytochrome c oxidase and Bcl-2 family in rat heart. Methods Sixty Sprague–Dawley rats were randomized assigned into two groups: first, short-term intermittent hypobaric hypoxia (STIHH)-normobaric normoxia (n=10), hypobaric hypoxia (380 mmHg, 12% O2, 8 hr/day) for 1 day (n=10), and for 4 days (n=10) and second, long-term intermittent hypobaric hypoxia (LTIHH)-normobaric normoxia (n=10), hypobaric hypoxia for 1 week (n=10) and 2 weeks (n=10). After STIHH or LTIHH challenge, myocardial morphology, cytochrome c oxidase and pro-apoptotic Bcl-2 family in the excised left ventricle were determined by histological analysis, Western blotting, and RT-PCR. Results Increased wall thickness and abnormal myocardial architecture were observed after LTIHH. Cytochrome c oxidase and anti-apoptotic Bcl-2 protein were significantly increased after STIHH, but were decreased after LTIHH. Pro-apoptotic BNIP3 and Bad proteins were significantly decreased after STIHH but increased after LTIHH. Conclusions
Relation:	INTERNATIONAL JOURNAL OF CARDIOLOGY108(3):376~384
Appears in Collections:	[Department of Physical Therapy, Graduate Institute of Rehabilitation Science] Journal articles

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