Pro-inflammatory states and IGF-I level in ischemic heart disease with low or high serum iron.

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 健康照護學院 > 物理治療學系(停用) > 期刊論文 > Item 310903500/1595

請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/1595

題名:	Pro-inflammatory states and IGF-I level in ischemic heart disease with low or high serum iron.
作者:	李信達(Shin-Da Lee);黃志揚(Chih-Yang Huang);(Shu, Win-Tom);(Chen, Ter-Hsin);林子恩(Lin, Tzu-En);(Liu, Jer-Ynh);(Hsu, Hsi-Hsien);(Lin, Chung-Sheng);(Liu, Chung-Jung);郭薇雯(Wei-Wen Kuo);(Chen, Li-Mien)*
貢獻者:	健康照護學院物理治療學系
日期:	2006
上傳時間:	2009-08-19 17:03:59 (UTC+8)
摘要:	Background Serum iron overload or iron deficiency appears to be associated with atherosclerosis and ischemic myocardial damage. Roles of low or high serum iron in patients with ischemic heart diseases are still controversial. Methods Serum samples for biochemical and immunologic analyses were collected from the 73 normal subjects and the 90 patients with ischemic heart disease (IHD), the latter of which were selected from 142 patients and classified by low, normal and high serum iron. Results Tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), high sensitive C-Reactive protein (hsCRP), and interleukin-10 (IL-10) were increased and insulin-like growth factor (IGF)-I was decreased in IHD patients with low serum iron, whereas these parameters were not changed in IHD patients with normal or high serum iron, compared with normal subjects. Total bilirubin was increased in IHD patients with high serum iron but was not changed in IHD patients with low or normal serum iron, compared with normal subjects. Conclusion The IHD patients with low serum iron were associated with a pro-inflammatory state, such as increased TNF-α, IL-6, and hsCRP; increased anti-inflammatory activities, such as increased IL-10; decreased cardiac protective factor, such as decreased IGF-I. These findings may imply that IHD patients with low serum irons were associated with less cardiac protection and more pro-inflammatory states than normal subjects or IHD patients with either normal or high serum iron.
關聯:	CLINICA CHIMICA ACTA370(0):50~56
顯示於類別:	[物理治療學系(停用)] 期刊論文

文件中的檔案:

檔案	大小	格式	瀏覽次數
	0Kb	Unknown	515	檢視/開啟

在CMUR中所有的資料項目都受到原著作權保護.

TAIR相關文章

資料載入中.....